There is no report on preimplantation phase endometrial transcriptomics in natural conception cycles of primates. In the present study, whole-genome expression array endometrium Days 2, 4, and 6 post-ovulation (pov) proven (Group 1; n = 12) non-mated, ovulatory 2; rhesus monkeys was examined, compared, validated. Of fifteen (15) genes showing differential (>2-fold; pFDR < 0.05), six (CHRN...

Targeted Rearrangement of Floxed Alleles in Smooth Muscle Cells in Vivo To the Editor: In their biologically and technically important article “Development of a Smooth Muscle-targeted Cre Recombinase Mouse Reveals Novel Insights Regarding Smooth Muscle Myosin Heavy Chain Promoter Regulation”,1 Regan et al reported generation of mice that express cre recombinase from a fragment of the smooth mus...

A 3-year-old boy being followed up for bilateral club foot underwent a routine thorax radiography that revealed aortic arch enlargement. Echocardiography showed sinus of Valsalva dilatation. Because of clinical features such as hypertelorism, bifid uvula, and prominent forehead, a genetic investigation was conducted that confirmed Loeys-Dietz syndrome (LDS) by identifying a heterozygous mutatio...