The ability to engineer biological circuits that process and respond to complex cellular signals has the potential to impact many areas of biology and medicine. Transcriptional activator-like effectors (TALEs) have emerged as an attractive component for engineering these circuits, as TALEs can be designed de novo to target a given DNA sequence. Currently, however, the use of TALEs is limited by...

I suppose the beginnings were recognisable in medicine and medical education as long ago as 1875, when a poor frustrated Coughtrey, appointed the first professor of anatomy and physiology and trying to establish a medical school in the University of Otago, was battling with the university council. In the despair of his non-progress, in a relationship that was always fragile, he wrote that if th...

Interpretation of Student Programs as a Strategy for Courseware Development Colin G. Johnson University of Kent at Canterbury, England [email protected]