It was a sunny September day in a Madrid that had started to grow after years of stagnation, when I entered a modern red brick building at the corner of Velázquez and Joaquín Costa streets. I had an appointment with someone unknown to me, but whom I had been told was an important enzymologist. I was far from imagining that the encounter with that person would determine my future scientific life...

Nanoscale entities are by definition invisible to the unmediated senses. Yet generating images of these objects has been crucial to the rhetoric of nanotech boosters. Thus, bringing microscopes and microscopists under the nano umbrella has been central to the work of nano proponents. No instruments have been more crucial to this process than the scanning tunneling microscope (STM) and atomic fo...

Yolk retention and yolk sac infection is considered as an important cause of death in chicken as well as in guinea fowl, duck, turkey, quail and goose. The factors which slow down the rate of yolk absorption and may in turn, lead to yolk retention are discussed. Yolk sac infection of bacterial origin is most important among these factors. Other factors which may contribute include posthatch sta...

AIMS The present study aimed to determine whether yolk sacs with abnormal sonographic appearance are associated with adverse perinatal outcomes in both early and late gestation. MATERIAL AND METHODS A total of 305 viable singleton pregnancies with gestational age of 6 to 9 weeks were prospectively evaluated with respect to perinatal outcomes and sonographic characteristics of the yolk sacs. ...

(Pinacolato)boryl ortho-silyl(hetero)aryl triflates are presented as a new class of building blocks for arylation. They demonstrate unique versatility by delivering boronate or (hetero)aryne reactivity chemoselectively in a broad range of transformations. This approach enables the unprecedented postfunctionalization of fluoride-activated (hetero)aryne precursors, for example, as substrates in t...

2,6-Di(hetero)aryl and 2-(hetero)aryl substituted dithienothiazines are prepared from N-aryl dithienothiazines by a lithiation–lithium–zinc exchange–Negishi cross-coupling sequence with (hetero)aryl iodides in a one-pot fashion in good to excellent yields. These novel extended π-electron systems can be reversibly oxidized and fine-tuned in their electronic properties as supported by cyclo volta...