Journal:
:research in molecular medicine
0
reza valadan molecular and cell biology research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
alireza rafiei molecular and cell biology research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
mohsen tehrani molecular and cell biology research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
forough nejatollahi recombinant antibody laboratory, department of immunology, faculty of medicine, shiraz university of medical sciences, shiraz, iran
production and approval of trastuzumab (herceptin®) for the treatment of metastatic breast cancer (mbc) was a millstone in antibody-based targeted therapy in the cancer treatment. however, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. the majority of patients who benefit from the drug acqui...