BACKGROUND Busulfan demonstrates a narrow therapeutic index for which clinicians routinely employ therapeutic drug monitoring (TDM). However, operationalizing TDM can be fraught with inefficiency. We developed and tested software encoding a clinical decision support tool (DST) that is embedded into our electronic health record (EHR) and designed to streamline the TDM process for our oncology pa...

Levetiracetam (LEV) is a broad spectrum antiseizure medication that used in various seizure types. There evidence therapeutic drug monitoring (TDM) of LEV value selected patient populations, therefore determination plasma concentrations essential. Herein we developed and validated simple, reproducible, practical method for the quantification human samples using high performance liquid chromatog...

Subtherapeutic levels of lamotrigine and levetiracetam are more likely to occur during pregnancy owing to the effect of pregnancy on their pharmacokinetics. This can lead to suboptimal control of epilepsy, and guidelines recommend proactive dose adjustment in the second and third trimesters alongside therapeutic drug monitoring (TDM). This retrospective cohort study using administrative databas...

Lithium represents the main drug for treatment of Bipolar Disorder (BD) as it acts a mood stabilizer. However, because its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital control their lithium blood concentration during therapy. In this paper, we fabricate first time complete non-invasive system Therapeutic Drug Monitoring (TDM) sweat people suffering f...

PURPOSE Although vancomycin (VCM) is not absorbed from healthy intestinal mucosa, elevations in the serum VCM concentrations have been reported in some cases. The aims of this study are to evaluate the necessity of therapeutic drug monitoring (TDM) during enteral VCM administration in critically ill patients. MATERIALS AND METHODS In this retrospective study, we enrolled 19 patients admitted ...

Therapeutic drug monitoring (TDM) has consistently been shown to be useful for optimization of drug therapy. For the first time, a method has been developed for the text analysis of TDM in SPCs in that a catalogue SPC-ContentTDM (SPCCTDM) provides a codification of the content of TDM in SPCs. It consists of six structure-related items (dose, adverse drug reactions, drug interactions, overdose, ...

BACKGROUND Since the early 1970s therapeutic drug monitoring (TDM) of anti-epilepsy drug (AED) levels has been available to assist in the review process of patients with epilepsy. Routine blood levels were not part of the Quality and Outcomes Framework in the New GP Contract, neither have they been generally recommended in National Guidelines (NICE and SIGN) for the management of patients with ...

Voriconazole is an antifungal triazole that is the first line agent for treatment of invasive aspergillosis. It is metabolized by CYP2C19, CYP2C9, and CYP3A4 and demonstrates wide interpatient variability in serum concentrations. Polymorphisms in CYP2C19 contribute to variability in voriconazole pharmacokinetics. Here, evidence is examined for the use of voriconazole therapeutic drug monitoring...

Anticancer drugs are notoriously characterized by a low therapeutic index, the introduction of drug monitoring (TDM) in oncologic clinical practice could therefore be fundamental to improve treatment efficacy. In this context, an attractive technique overcome conventional venous sampling limits and simplify TDM application is represented dried blood spot (DBS). Despite significant progress made...

Introduction Therapeutic Drug Monitoring (TDM) is an evolving tool used to optimise the administration of antimicrobial agents; which are well documented to have toxic side effects [1]. In combination with increasing antimicrobial resistance and emphasis on cost-efficiency, provision of the optimal dose of antimicrobial therapy is a very attractive prospect. Pharmacokinetic (PK) indices can be ...