blocking antibodies are valuable tools for inhibiting the specific receptor- ligand interactions. the interaction of co-stimulatory molecules on the antigen presenting cells with their ligands on t cells is an essential step for t cell activation. in the present study, the effect of blocking antibody against cd40 on its t cell stimulatory potential is investigated. the dcs (dendritic cells) wer...

Spatio-temporal variation in heat-shock gene expression gives organisms the ability to respond to changing thermal environments. The temperature at which heat-shock genes are induced, the threshold induction temperature, varies as a function of the recent thermal history of an organism. To elucidate the mechanism by which this plasticity in gene expression is achieved, we determined heat-shock ...

Using mRNA differential display, we found that the gene for NAD(+)-dependent glycerol phosphate dehydrogenase (GPDH; EC 1.1.1.8) is induced in rat brain following seizure activity. Northern blot and in situ hybridization analysis confirmed the differential display results; they also showed, in a separate model of neuronal activation, that after thermal noxious stimulation of the hind-paws, a si...

Negative affective states influence pain processing in healthy subjects in terms of augmented pain experience. Furthermore, our previous studies revealed that patients with major depressive disorder showed increased heat pain thresholds on the skin. Potential neurofunctional correlates of this finding were located within the fronto-thalamic network. The aim of the present study was to investiga...

In this paper, the classical Direct Torque Control (DTC) of Induction Motor (IM) using an open loop pure integration suffers from the well-known problems of integration especially in the low speed operation range is detailed. To tackle this problem, the IM variables and parameters estimation is performed using a recursive non-linear observer known as EKF. This observer is used to estimate the s...

Abstract This article addresses the impact of magnetic field induction on buoyancy-induced oscillatory flow couple stress fluid with varying heating. Modelled equations for incompressible are coupled and nonlinear due to inclusion viscous heating thermal effect density. Approximate solutions constructed coded a symbolic package ease computational complexity. Graphical representations presented ...

The results of the study working conditions in aluminum casting shops worksites are presented. these studies showed that there exceedance permissible limits for noise, vibration, content harmful substances environment, intensity infrared (thermal) radiation and air temperature. There is effect electromagnetic on workers during service induction furnaces. In addition, main production factors inc...

Ignition and combustion of an initially spherical pocket of fuel in motion relative to a hot oxidizing atmosphere is studied. The model considers finite rate chemistry represented by an irreversible one-step reaction. Attention is focused on the development of the ignition process, which, in the end, typically leads to the establishment of a diffusion flame. For moderate values of a suitably de...

Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3-28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Nav1.7 protein and mRNA expression...

background: the purpose of this study was to investigate the enhanced thermal resistance mechanism of the du145 tumor spheroid cultures as compared to the prostate carcinoma cell line's monolayer cultures. materials and methods: du145 cells were cultured either as spheroids or monolayers. cultures were treated with hyperthermia in a precision water bath (at 43°c for 60 minutes) and/or quercetin...