cancer is a leading cause of death worldwide. despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. in this contribution, a series of 11 dhps (4a, 4b & 7a-i) were synthesized and evaluated for their cytotoxic effect against mcf-7, ls180, and molt-4 cancer cell lines using mtt assay. synthesized 2,6-di...

ABSTRACT. The versatile scaffold, N'-(2-cyanoacetyl)-2-hydroxybenzohydrazide (3) was utilized in the production of new pyridine, chromene and thiazole derivatives as antimicrobial antioxidant agents. synthetic strategy involves treatment precursor 3 with various arylidene-malononitrile 3-aryl-2-cyanoacrylate compounds to furnish substituted pyridines 5 7. interaction salicylaldehyde and/or phen...

3-[(2'-Substituted benzylidene amino thiazol-4'-yl) amino] coumarins (5a-5d) and 3-[(2'-Substitutd benzylidine amino oxazole-4'-yl) amino coumarins (8a-8d) were prepared by the reaction with compounds 4 and 7 respectively with various substituted aldehydes in the presence of glacial acetic acid. All the synthesized compounds 120 have been screened for their antibacterial and antifungal activiti...

The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole s...

Approximately 6% of dog platelets are positive for staining with thiazole orange, a dye frequently used to stain ribonucleic acid. In this report, thiazole-orange positivity is shown to mark platelets that are less than 24 hours old. Dog platelets were derivatized in vivo with N-hydroxysuccinimido biotin such that greater than 95% of all platelets were biotinylated. Newly synthesized, nonbiotin...