Bruch’s membrane is a thin (2–4 μm), acellular, five-layered extracellular matrix located between the retina and choroid. It extends anteriorly to the ora serrata, interrupted only by the optic nerve. Tissue resembling Bruch’s membrane is visible anterior to the ora serrata extending forward to the pigmented epithelium of the ciliary body. Bruch’s membrane lies between the metabolically active ...

The iris vascular bed of eyes with pseudoexfoliation syndrome has been studied with electron microscopy. Two of the eyes suffered from painful glaucoma, whereas the third showed normal intraocular pressure. The following changes were observed: (1) deposits of pseudoexfoliation material lying adjacent to the endothelial wall; (2) thin vessel basement membrane, sometimes even interrupted; (3) ext...

Chromatography is an important biophysical technique that enables the separation, identification, and purification of the components of a mixture for qualitative and quantitative analysis. Proteins can be purified based on characteristics such as size and shape, total charge, hydrophobic groups present on the surface, and binding capacity with the stationary phase. Four separation techniques ba...

We introduce a simplified model for thin layer flows of granular materials with yield. The model is derived from a Drucker–Prager rheology, and describes the dynamics of the velocity profile and of the transition between static and flowing material. We compare the analytical solution in the inviscid case, and the numerical solution in the viscous case, to experimental data. Although the model d...

We established a new highly sensitive method, PCR-ELISA, for the dectection of Babesia bovis in cattle for farms in Thailand. The detection of around 2.4 x 10(-8)% parasitemia (equivalent to 1 infected erythrocyte per 2 ml) was achieved by PCR amplification followed by the ELISA detection of a biotin tagged gene. When comparing the sensitivity of PCR-ELISA with the microscopic method, our PCR-E...

This paper describes the design, implementation and validation of a sensitive and integral technology solution for endotoxin detection. The unified and portable platform is based on the electrochemical detection of endotoxins using a synthetic peptide immobilized on a thin-film biosensor. The work covers the fabrication of an optimized sensor, the biofunctionalization protocol and the design an...

The widespread availability of cloud infrastructures is fueling new interest in the thin client computing paradigm. However, current thin client protocols are not designed to handle new content types as often encountered in state-ofthe-art applications (e.g. multimedia editing, gaming, multimedia playback). Conveying this content using traditional thin client protocols typically results in a co...

PURPOSE To explore whether and how longitudinal medical records could be used as a source of reference in the early phases of signal detection and analysis of novel adverse drug reactions (ADRs) in a global pharmacovigilance database. METHODS Drug and ADR combinations from the routine signal detection process of VigiBase® in 2011 were matched to combinations in The Health Improvement Network ...

In this paper, we present the exact solution of the Riemann problem for the nonlinear one-dimensional so-called shallow-water or Saint-Venant equations with friction proposed by SAVAGE and HUTTER to describe debris avalanches. This model is based on the depth-averaged thin layer approximation of granular flows over sloping beds and takes into account a Coulomb type friction law with a constant ...

Fabrication of tunable fine textures on solid metal surfaces often demands sophisticated reaction/processing systems. By exploiting in situ polymerization and self-assembly inorganic adducts derived from liquid metals (the so-called HetMet reaction) with concomitant solidification, films texture are readily fabricated. Serving as a natural dimensional confinement, interparticle pores capillary-...