In the Eastern Mediterranean Region (EMRO), there are no accurate estimates of numbers of patients with multidrugresistant (MDR)/extensively drug-resistant (XDR) tuberculosis (TB). In 2006, we documented the existence and transmission of XDR-TB among patients with MDR-TB [1]. In a further study, we isolated more dangerous forms of bacilli, named totally drug-resistant (TDR) [2]. This group of s...

TRH analogues containing C-terminal tioamide group and norvaline ([Nva2, Prot3] TRH) or norleucine ([Nle2, Prot3] TRH) in position 2 were synthesized and tested for hormonal and central nervous system (CNS) activities. Receptor binding studies revealed that the analogues neither bind to pituitary nor to brain TRH receptors. Accordingly, no TSH releasing activity was recorded. However, both anal...

BACKGROUND Thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. RESULTS A novel series of thiazoles carrying 1,3,4-thiadiazole core were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbo-thioamide with the appropriate hydrazonoyl chlorides. The structures of the newly synthesized compound...

2-(pyridine-2-yl)-N-p-chlorohydrazinecarbothioamide (HCPTS) was synthesized, characterized and successfully applied for the preconcentration of Cu(II), Ni(II), Zn(II), Cd(II), Co(II), Pb(II), Fe(II), and Hg(II) in water, blood, and urine samples prior to graphite furnace atomic absorption determination (GFAAS); Hg was determined by cold vapor technique. Under the optimum experimental conditions...

4. Petersson I, Nilsson G, Hansson BG, Hedner T. Water intoxication associated with non-steroidal anti-inflammatory drug therapy. Acta Med Scand. 1987;221:221--3. 5. Blum M, Aviram A. Ibuprofen induced hyponatraemia. Rheumatol Rehabil. 1980;19:258--9. 6. Gomez Garcia EB, Ruitenberg A, Madretsma GS, Hintzen RQ. Hyponatraemic coma induced by desmopressin and ibuprofen in a woman with von Willebra...

The self-assembly of small and well-defined molecules using noncovalent interactions to generate various nano- and microarchitectures has been extensively studied. Among various architectures, one-dimensional (1-D) nano-objects have garnered significant attention. It has become increasingly evident that a cooperative or nucleation-elongation mechanism of polymerization leads to highly ordered 1...