Recent studies have indicated that peroxidase might function in the biological synthesis of thyroxine by the thyroid gland. Johnson and Tewkesbury (1) believed that thyroxine might be formed by the oxidative coupling of 2 molecules of diiodotyrosine. Westerfeld and Lowe (2) studied the oxidative condensation of p-cresol by hydrogen peroxide and peroxidase and suggested that peroxidase might be ...

Lurie et al. ' have found that administration of thyroid hormones can increase the level of native resistance to tuberculosis in rabbits, and that thyroidectomy and antithyroid drugs have the opposite effect. On the other hand, the harmful effects of iodides on the clinical manifestations of human leprosy are well known. 0 'Byrne2 and Roj as' have reported favourable responses in the treatment ...

RNA levels are determined by the rates of both transcription and decay, and a mechanistic understanding of the complex networks regulating gene expression requires methods that allow dynamic measurements of transcription and decay in living cells with minimal perturbation. Here, we describe a metabolic pulse-chase labeling protocol using 4-thiouracil combined with large-scale RNA sequencing to ...

Relatively few studies have been made of the influence of the thyroid gland on the development and growth of tumors. Lerman (15) stated that the thyroid does not greatly influence the onset and growth of either experimental or human cancer, but Rawson (17) recently cited some experimental and clinical observations which suggest that hyperthyroidism may inhibit, while hypothyroidism may enhance,...

and color of the treated area which has been suggeste(l to act as a metabolic siiik (6). The stimulation of both RNA and l)rotein synthesis b) kinetic in tobacco (8) aiid Xmanthinmn (7) leaves has been reported, lanl MIcCalla, 'Moore and Osborne (5) using another kinin, the benzyladenine-C14, have obtained tentative evideence that label was incorporated into RNA although at a very low rate. Wol...