MicroRNAs are heterochronic molecules important during brain development, which could be altered by gestational diabetes mellitus (GDM). To explore these molecules in maternal serum, we performed an RT-qPCR analysis. Our results revealed the heterochronic character of some neural development-related microRNA in serum samples of pregnant women. In relation to the first trimester, higher levels o...

A randomized clinical trial (RCT) noted that sonographic examination in the third trimester, in conjunction with delivery at term for abnormalities of fetal growth, significantly decreased the likelihood of small-for-gestational-age (SGA) neonates in uncomplicated pregnancies. We identified 15 characteristics of screening tests and attempted to determine if there is evidence to routinely obtain...

INTRODUCTION Spontaneous rupture of uterus in unscarred uterus prior to onset of labor in third trimester is extremely rare and to our knowledge, very few cases have been reported so far. CASE PRESENTATION A 26-year-old third gravida women with 32 weeks pregnancy presented with pre-labor rupture uterus with extrusion of intact amniotic sac from the rent in uterine fundus. CONCLUSION Rupture...

Abstract Background Gestational diabetes mellitus (GDM), one of the most common pregnancy complications, can lead to morbidity and mortality in both mother infant. Metabolomics has provided new insights into pathology GDM systemic analysis with metabolites is required for providing more clues diagnosis mechanism research. This study aims reveal metabolic differences between normal pregnant wome...

OBJECTIVES Maternal docosahexaenoic acid (DHA) intakes is important for brain development in fetuses. Accurate assessment of EPA and DHA intakes is required in clinical settings to identify women with deficiency of these nutrients and provide an appropriate intervention for them. We examined the validity and reproducibility of a brief-type self-administered diet history questionnaire (BDHQ) for...

BACKGROUND Vitamin D deficiency has become a global health issue in pregnant women. This study aimed to assess the adequacy of maternal vitamin D status by measuring maternal serum and breast milk 25-hydroxyvitamin D [25(OH)D] levels and to determine the association between maternal serum and milk 25(OH)D levels. METHODS Data was obtained from the Universiti Sains Malaysia Pregnancy Cohort St...

BACKGROUND Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications. OBJECTIVE We prospectively evaluated the associations of maternal air pollution exposure with markers of placental growth and function among 7,801 pregnant women in the Netherlands. METHODS We estimated levels of particulate matter ≤ 10 µm in aerodynamic...

BACKGROUND The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. OBJECTIVE We studied prenatal lead exposure's impact on neurodevelopment using repeated measures of fetal dose as reflected by maternal whole blood and plasma lead levels. METHODS We meas...