TYPE: Case Report TOPIC: Critical Care INTRODUCTION: Factitious use of insulin, thyroxine, decongestants, laxatives, cocaine, and heroin have been reported to cause hypokalemia. Severe hypokalmeia < 2 mg/L can rhabdomyolysis, arrythmias, seizures warrenting rapid correction. CASE PRESENTATION: A 22-year-old male with recent cocaine presented intractable vomiting, ascending weakness tingling for...

Polyphor's macrocycle platform led to the discovery of novel antibiotics addressing specifically Gramnegative bacteria by targeting outer membrane proteins. Furthermore, POL6014, an inhibitor neutrophile elastase and balixafortide, a CXCR4 have been discovered developed from platform. Currently combination balixafortide eribulin is in Phase III clinical trial for treatment patients with advance...