The most important specific regulatory mechanism for hepatic angiotensinogen synthesis and secretion is its stimulation by angiotensin II, the effector peptide of the renin-angiotensin system. In the circulating system, this octapeptide is thought to stimulate hepatic angiotensinogen synthesis through a positive feedback loop. In the present study, we have identified the intracellular mechanism...

Caffeine is synergistic with many DNA-damaging agents in increasing lethality to mammalian cells. The mechanism is not well understood. Our results show that caffeine potentiates the lethality of the nitrogen mustard 2-chloro-N-(2-chloroethyl)-N-methylethanamine (HN2) by inducing damaged cells to undergo mitosis before properly repairing lesions in their DNA. Treatment with low doses of HN2 (0....

e nature of divine eternality is obscure in both historical andmodern discussions. In a way its obscurity is no surprise, given that the nature of time is so mysterious. But the obscurity is still notable relative to the other traditional divine attributes, which are comparatively much better understood. Our perplexities regarding eternality are compounded, I will argue here, by a failure to re...

H ow do smalland medium-sized firms raise external equity capital? In this paper, I describe two markets that entrepreneurs of smalland medium-sized enterprises use in the United States to raise equity: the organized private equity market and the market for angel capital. Both markets are important sources of equity capital for smalland mediumsized firms. However, until recently, not much was k...

metals can cause oxidative stress by increasing the formation of reactive oxygen species (ros), which make antioxidants incapable of defiance against growing amounts of free radicals. metal toxicity is related to their oxidative state and reactivity with other compounds. however, several reports about metals have been published in the recent years. mitochondria, as a site of cellular oxygen con...

a general robotic mechanism was presented for in-pipe inspection oflevel pipes with varied diameter or curved pipelines. the robot employed three legs comprised of parallelogram linkages mechanism which enables adapting to various elbow joints in the piping systems. the curvatures in pipeline are the most important constraints in front of the robot through navigation process. to study the adapt...