Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old responses, there is extensive cross-talk between inflammation and coagulation in enabling an adequate immune response against potentially injurious stimuli. Immune cells are important in the initiation of coagulation pathways, while various inflammatory mediators are capable of altering haemostasis. Vice ve...

V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein, can induce membrane protrusions in various cells. Vstm5 can modulate both the position and complexity of central neurons by altering their membrane morphology and dynamics. In this study, we investigated the significance of glycosylation in the expression and function of Vstm5. Four N...

Abstract MYC is embedded in the transcriptional oasis of 8q24 gene desert. A plethora genomic elements has roles aberrant expression cancer development by interacting with transcription factors and epigenetics regulators as well altering structure chromatin at locus tissue-specific long-range enhancer–promoter contacts. Furthermore, a master regulator several human cancers modulating numerous c...

Enterprise roles define the duties and responsibilities of the individuals which are assigned to them. This paper introduces a framework for the management of large distributed systems which makes use of the concepts developed in role theory. Our concept of a role groups the specifications of management policies which define the rights and duties corresponding to that role. Individuals may then...

The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modelling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential...