The surgical strategy in patients with myasthenia gravis (MG) is influenced by the suspicion of thymoma based on mediastinal imaging. Aim of this retrospective study was to analyse the accuracy of CT of the mediastinum in predicting the histological findings in patients with MG referred for thymectomy. Thirty-four CT-scans of MG patients referred for thymectomy between October 1989 and October ...

An adoptive transfer system was used to examine the capacity of cellular inocula from rats fully tolerant of Ag-B antigens to transfer tolerance to irradiated recipients. Permanent tolerance in these irradiated recipients involved specific suppression of the regenerating immune response. Cells obtained from tissues rich in recirculating lymphocytes were the most effective suppressors. Highly pu...

BACKGROUND Autoimmune rheumatic diseases (ARDs), involving immune disturbances resulting from auto-inflammatory mechanisms, are a group of diseases characterized by autoimmunity and autoimmunemediated organ damage. Thymoma, whose mechanism is also associated with immune abnormalities, is the most common neoplasm of the anterior mediastinum. But thymoma with ARDs is relatively less frequent. The...

induced tumors in experimental animals (16, 21, 24). Nevertheless, there are some exceptions to this generalization. The effect of neonatal thymectomy on the incidence of viral-induced leukemias in mice is inhibitory (17). Immuno depression also inhibits the development of tumors of the mouse mammary gland induced by the MTV. There have been several reports that neonatal thymectomy decreases ma...

OBJECTIVE A few thymoma patients without myasthenia gravis (MG) have been observed to develop MG after total removal of the thymoma (postoperative MG). However, the cause of this is not yet known because of the rarity of postoperative MG patients. This study evaluated the clinical characteristics of the 8 postoperative MG patients. METHODS We compiled 1089 thymoma patients treated between 199...

Experimental gastritis was produced in BALB/c (? / +) mice by the method of neonatal thymectomy. This atrophic gastritis was confined to the gastric fundobody mucosa and spared antrum. The morphological changes in the gastric mucosa of this type of gastritis have been described in detail during the growth process after thymectomy (1, 2, 3, 6, 10, and 15 months). The mucosa! changes developed fr...

OBJECTIVES Thymectomy is a recognized treatment for myasthenia gravis (MG), but the optimal surgical approach is yet to be determined. This study analysed the results in non-thymomatous MG patients treated at our institution using an extended transcervical access with partial upper sternotomy (TC-US), in order to describe cumulative incidence of remission and its predictors. METHODS In the pe...