The thymus is the primary organ responsible for generating functional T cells in vertebrates. Although T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress. The past decade, however, has seen a renewed interest in thymus organogenesis, with the aim of understanding how the thymus develops to form a microen...

In this study, the chemical composition of essential oils obtained from aerial parts Thymus longicaulis subsp. naturally grown in Turkey were analyzed by GC and GC-MS differences terms chemotaxonomy discussed. The main compounds T. 1,8-cineole (30.1%), linalool (18.0%), β-pinene (17.3%) (E)-β-ocimene (%12.6%) Hierarchical cluster analysis was performed examining oil studies 34 samples belonging...

BACKGROUND The impairment of immune functions associated with malnutrition may be one reason for the high mortality in children with severe acute malnutrition (SAM), and thymus atrophy has been proposed as a marker of this immunodeficiency. The aim of this study was to identify nutritional and clinical correlates of thymus size in children with SAM, and predictors of change in thymus size with ...

Resident mesenchymal stromal cells (MSCs) are involved in angiogenesis during thymus regeneration. We have previously shown that MSCs can be isolated from enzymatically digested human neonatal and infant thymus tissue that is normally discarded during pediatric cardiac surgical procedures. In this paper, we demonstrate that thymus MSCs can also be isolated by explant culture of discarded thymus...

The ability of thymus to restore the immune deficiency produced by neonatal thymectomy in mice decreases with the delay of treatment after thymectomy (1). Eventually a state is reached when thymus grafts become ineffective, especially when the animals develop the postthymectomy-wasting syndrome (2, 3). These results were interpreted as indicating that a population of cells in the host, capable ...

The nature of the cells that seed the thymus of an irradiated recipient after intravenous (IV) transfer of bone marrow (BM) cells was investigated using 2 approaches. First, direct entry of a small number of donor BM cells into the thymus was tracked using a Ly-5 marker. Second, secondary IV transfer of the seeded thymus cells into a secondary recipient was used as an assay for precursor activi...

Thymus vulgaris has gained tremendous popularity as an ornamental, culinary herb and its use in phytotherapy is well established and supported in the literature. The objective of this study was to explore possible interactions between selected molecules within Thymus vulgaris essential oil (TvEO) to gain a better understanding of how this complex essential oil exerts its antimicrobial activity....