BACKGROUND Medullary thyroid carcinomas (MTC) constitute about 5 to 7% of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum calcitonin can be negative. CASE PRESENTATION We report on a 73-year-old female patient with a rare...

INTRODUCTION In this report, we describe a rare case of papillary thyroid carcinoma with adrenocortical carcinoma without excess hormone production. CASE PRESENTATION A 40-year-old Turkish man was admitted to our institution with a large left adrenal mass that was identified during the work-up for shortness of breath. The patient did not have specific signs and symptoms of hormone excess. The...

INTRODUCTION Thyroid gland is a rare site of clinically detectable tumor metastasis. CASE REPORT A 71-year-old woman was referred to our department for an evaluation of toxic multinodular substernal goiter. She had a history of renal clear cell carcinoma of the left kidney, which had been resected 2 years previously. US confirmed the multinodular goiter. Total thyroidectomy with neuromonitori...

BACKGROUND Clinically evident cardiac metastases from malignant neoplasms are uncommon. The frequency of thyroid metastasis to the heart is very low. To our knowledge, over the last 20 years only a few cases have been reported in the entire literature. Metastatic cardiac involvement occurs most often during the terminal stage. PATIENTS We present three cases of anaplastic thyroid cancer with ...

Being one of the most lethal human neoplasms and refractory to such conventional treatment as chemo- and radiotherapy, anaplastic thyroid carcinoma is a prime target for innovative therapy. p53 gene inactivation is a constant feature of this neoplasia. Therefore, we evaluated a therapeutic approach based on an E1B 55-kDa gene-defective adenovirus (ONYX-015) that replicates only in cells with im...

Cowden syndrome (multiple hamartoma syndrome, MIM 158350) is an early onset syndrome characterized by multiple hamartomas in the skin, mucous membranes, breast, thyroid and endometrium. Patients with Cowden syndrome have increased risk of breast cancer, thyroid cancer and endometrial cancer. In 1997 germline mutations in PTEN were demonstrated to cause Cowden syndrome. We report the results of ...

Renal carcinoma cell is responsible for 3e4% of all neoplasms and 80e85% of malignant tumors of the renal cortex. The most frequent histological subtypes are: clear cells (approximately 75%), papillaries (10%), chromophobes (5%), oncocytoma (8%), angiomyolipoma (<1%). Among the less common histological types are the medullary carcinomas (1%), collecting ducts (1%), Xp11 translocation (<1%) and ...

Twenty-five patients with solitary cold thyroid nodules (SCN) were studied by fine needle aspiration (FNA) cytology, radionuclide perfusion scanning (RPS) and pentavalent technetium dimercaptosuccinic acid (99m Tc DMSA) scanning, with an aim to distinguish neoplastic from non-neoplastic nodules. All the patients were operated upon and the nodules were subjected to histopathological examination....

Mature cystic teratoma (MCT) is a common ovarian neoplasm in young females. A secondary malignant transformation occurs rarely in cystic teratomas at an older age. These secondary malignant neoplasms most commonly are squamous cell carcinomas (SCCs). Various mechanisms are reported, but the exact aetiology is unknown. We report three cases of SCC arising in cystic teratoma and one case of papil...

Background and Objectives : Fine needle Aspiration cytology (FNAC) plays an important role in the evaluation of the nodules in the thyroid gland & selection of patients for surgical treatment. The present study was undertaken with the following aims and objectives:1. To study morphological features in thyroid aspirates. 2. To study the cytomorphologic attributes useful in distinguishing between...