A study was conducted to evaluate effects of different bone preparation methods on bone parameters and the correlations between bone breaking strength and the other bone parameters. Bone breaking strength is dramatically changed depending on bone preparation methods, whereas other bone parameters such as ash content and ash concentration are not significantly influenced by bone preparation meth...

High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS DXA scans. pQCT measurements from the mid and distal tibia and radius in 98 HBM...

AIM To assess the effect of anti-vascular endothelial growth factors (VEGF) on bone healing (defect volume) and implant osseointegration (bone-implant contact per cent) in rat tibia. MATERIALS AND METHODS In Sprague-Dawley rats (n = 36), a unicortical defect was created in the right tibia and a titanium implant was placed in the left tibia of each rat. Rats were assigned into three groups and...

Transient muscle paralysis engendered by a single injection of botulinum toxin A (BTxA) rapidly induces profound focal bone resorption within the medullary cavity of adjacent bones. While initially conceived as a model of mechanical disuse, osteoclastic resorption in this model is disproportionately severe compared with the modest gait defect that is created. Preliminary studies of bone marrow ...

Introduction: One of the commonly encountered surgical dilemmas for most orthopaedic trauma surgeons is the management of compound tibia fractures with significant bone defects. We used the Ilizarov technique to solve this complex problem using an ilizarov fixator over an intramedullary tibia nail. We present a case series of five such patients with compound tibia fractures with significant bon...

BACKGROUND Different bone cements and various cementation techniques can lead to different bone loss in revision surgery. We investigated the degree of tibial bone loss depending on different cements and techniques. METHODS 30 tibia specimens were matched into three groups (10 each). In all cases Genesis II tibia component were implanted. In two groups, the tibia base plate alone was cemented...

While it is widely acknowledged that bones adapt to the site-specific prevalent loading environment, reasonable ways to estimate skeletal loads are not necessarily available. For long bone shafts, muscles acting to bend the bone may provide a more appropriate surrogate of the loading than muscles expected to cause compressive loads. Thus, the aim of this study was to investigate whether mid-thi...

Cross-sectional and interventional studies suggest that high-intensity strength impact-type training provide a powerful osteogenic stimulus even in old age. However, longitudinal evidence on the ability of to attenuate age-related bone deterioration is currently lacking. This follow-up study assessed role continued sprint aging 40- 85-year-old male sprinters (n = 69) with long-term background. ...

Knee specimens of two osteoporotic patients who underwent unilateral knee arthroplasty for suspected osteonecrosis of the knee were examined histologically. Preoperative findings of magnetic resonance images in both patients were consistent with the diagnosis of osteonecrosis of the medial femoral condyles, although plain X-rays showed minimal degenerative changes. In both patients, preoperativ...

PURPOSE To evaluate the performance of composites consisting of fragmented cortical bone heteroimplant in association with methylmethacrylate preserved in 98% glycerin, in segmental bone defect of rabbit tibia medial metaphysis. METHODS In this study were used twelve adult New Zealand rabbits, divided into three groups of four animals each: G30 (30 days), G60 (60 days) and G90 (90 days). The ...