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تعداد نتایج: 2014976 فیلتر نتایج به سال:
We have reported that extent of proliferation atypical hepatocytes (POAH) in non-cancerous liver hepatocellular carcinoma and chromatin licensing DNA replication factor 1 (CDT1) are associated with postoperative recurrence. Here, we investigated whether POAH expression CDT1 also chemically induced cancer rats. Male Fisher strain rats were orally administered diethylnitrosamine (DEN) their drink...
In the last few years, an increasing interest in neuroprotective effect of cannabinoids has taken place. The aim present work was to study effects modulating cannabinoid receptor 1 (CB1) context light induced retinal degeneration (LIRD), using animal model that resembles many characteristics human age-related macular (AMD) and other degenerative diseases outer retina. Sprague Dawley rats ( n = ...
BACKGROUND Promoter methylation of the DNA repair gene, O-6-methylguanine-DNA methyltransferase (MGMT), is associated with improved treatment outcome for newly diagnosed glioblastoma (GBM) treated with standard chemoradiation. To determine the prognostic significance of MGMT protein expression as assessed by immunohistochemistry (IHC) and its relationship with methylation, we analyzed MGMT expr...
In leprosy, the nasal mucosa is considered as the principal route of transmission for the bacillus Mycobacterium leprae. The objective of this study was to identify M. leprae in the oral mucosa of 50 untreated leprosy patients, including 21 paucibacillary (PB) and 29 multibacillary (MB) patients, using immunohistochemistry (IHC), with antibodies against bacillus Calmette-Guérin (BCG) and phenol...
Canine distemper virus (CDV) causes a highly contagious disease, which has been reported in Taiwan for many years; however phylogenetic analysis of field CDV, histopathological lesions, and co-infection are poorly understood. The goals of this study were to characterize the pathology of CDV in dogs in Taiwan, and to assess the frequency of CNS demyelination in cases of CDV infection confirmed b...
Background and Objectives: Kerman Province, especially city of Bam in the southeast part of Iran, is epidemics for dry type cutaneous leishmaniasis (DTCL). This study was conducted to compare the effect of different treatments on parasite DNA load following therapies using Real-Time PCR method. Materials and Methods: Fifteen patients were divided into three groups under therapy with intralesio...
PURPOSE Although the incidence of microsatellite instability (MSI) accounts for 10-15% of cases of colorectal cancer, its clinical application for all colorectal cancers has widened. We attempted to identify clinical and pathological parameters that may be helpful in selection of patients with MSI-high (MSI-H). MATERIALS AND METHODS A total of 120 resected colorectal cancers were enrolled ret...
BACKGROUND Radiation-induced fibrosis (RIF) is one of the severe long-term side effects of radiation therapy (RT) with a crucial impact on the development of postoperative wound healing disorders (WHD). The grades of fibrosis vary between mild to severe depending on individual radiosensitivity. In this study, we have investigated the molecular pathways that influence RIF and have correlated dat...
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