In recent years the applications of NMR spectroscopy to the analysis of living systems have grown at a rapid pace. Initially these measurements were limited to excised tissues, and later extended to studies of perfused organs. With the new improvements in magnet technology and FT NMR techniques, in vivo measurements of intact animals and humans became possible. Most of these studies concentrate...

For health, well perfused tissues, oxygen uptake is determined primarily by metabolic need rather than by oxygen supply. Tissue hypoxia supervenes when tissue oxygen tension (PO2) falls below a critical point, and the point where this occurs can be predicted from the systemic oxygen delivery or extraction ratio. A growing body of evidence suggest that tissue oxygen extraction may be impaired in...

The Minisymposium on “Cell Migration in Tissues” focused on analysis of dynamic collective cell migration in several model systems and was cochaired by Alissa M. Weaver (Vanderbilt University Medical Center) and Celeste M. Nelson (Princeton University). The program highlighted both the physical forces exerted during migration and the signaling pathways involved in the process. Celeste Nelson (P...

The objective of this work is to develop endoscopic subsurface optical imaging technology that will be able to image different tissue components located underneath the surface of the tissue at an imaging depth of up to 1 centimeter. This effort is based on the utilization of existing technology and components developed for medical endoscopes with the incorporation of the appropriate modificatio...

Among clinical conditions w ith increased tissue iron, id iopathic hem o­ chrom atosis is un ique. I t is associated w ith increased absorption and iron deposition in all tissues. E xperim ental m odels to study iron absorption and deposition in tissues m ay p rovide inform ation on the processes associated w ith excess iron uptake. Low pro tein high fat d iets induced excess iron deposition in...