A novel approach to the synthesis of substituted piperazines and their investigation as N-type calcium channel blockers is presented. A common scaffold exhibiting high activity as N-type blockers is N-substituted piperazine. Using recently developed titanium and zirconium catalysts, we describe the efficient and modular synthesis of 2,5-asymmetrically disubstituted piperazines from simple amine...

Metal-Induced Lung Disease: Lessons from Japan’s Experience: Yukinori KUSAKA, et al. Department of Environmental Health, School of Medicine, Fukui Medical University—Metals inducing occupational respiratory diseases, e.g. metal fever, acute and chronic pneumonia, asthma, bronchitis, chronic obstructive lung disease, pulmonary fibrosis and lung cancer are described. The metals mentioned are the ...

We consider methods to define the performance metrics for different plasmonic materials to be used in localized surface plasmon applications. Optical efficiencies are shown to be better indicators of performance as compared to approximations in the quasistatic regime. The near-field intensity efficiency, which is a generalized form of the wellknown scattering efficiency, is a more flexible and ...

Reaction of the PEt3 adduct of a disilylated five-membered cyclic germylene with group 4 metallocene dichlorides in the presence of magnesium led to the formation of the respective germylene metallocene phosphine complexes of titanium, zirconium, and hafnium. Attempts to react the related NHC adduct of a disilylated four-membered cyclic germylene under the same conditions with Cp2TiCl2 did not ...

3. Introduction 3815 4. Group 3 Organo-hydroxides 3816 5. Group 4 Organo-hydroxides 3821 5.1. Titanium 3822 5.2. Zirconium 3823 5.3. Hafnium 3824 6. Group 5 Organo-hydroxides 3825 6.1. Vanadium 3825 6.2. Niobium 3825 6.3. Tantalum 3826 7. Group 6 Organo-hydroxides 3826 7.1. Chromium 3826 7.2. Molybdenum 3826 7.3. Tungsten 3829 8. Group 7 Organo-hydroxides 3830 8.1. Manganese 3830 8.2. Techneciu...

The aim of this study is to compare the metallic and natural fiber reinforced polymer composite bone plates used in humerus fractures. A 3D finite element model was developed to analyze the performance of both types of plates. This study proposed on fabrication of natural fiber powdered material (like Sisal (Agave sisalana), Banana (Musa sapientum) and Roselle (Hibiscus sabdariffa)) Reinforced ...

We systematically assessed the cytotoxic effects of five metallocene dichlorides containing vanadium (vanadocene dichloride), titanium (titanocene dichloride), zirconium (zircodocene dichloride), molybdenum (molybdocene dichloride), and hafnium (hafnocene dichloride) as the central metal atom and 19 other vanadocene complexes. These compounds were tested against the human testicular cancer cell...

IP traffic in the core and access networks increases rapidly by the speed-up of the access network and the spread of the rich applications. 10 Gigabit Ethernet (10 GE) becomes a popular link technology to connect IP routers and Ethernet switches not only intra-office transmission links but also inter-office long reach transmission links. The optical layer protection switching is expected to pro...

A metallurgical zirconium nitride (ZrN) layer was fabricated using glow metallurgy using nitriding with zirconiuming prior treatment of the Ti6Al4V alloy. The microstructure, composition and microhardness of the corresponding layer were studied. The influence of this treatment on fretting wear (FW) and fretting fatigue (FF) behavior of the Ti6Al4V alloy was studied. The composite layer consiste...

Rietveld analyses of neutron diffraction data collected on a series of Pb(Zr0.5Ti0.5)O3 samples, which had been prepared by sol-gel and conventional mixed oxide methods, showed that each sample contained both rhombohedral and tetragonal PZT (Pb[Zr1-xTix]O3). The zirconium-to-titanium ratio in the two phases was found to be markedly different. Pair distribution functions were also calculated for...