Posttranscriptional regulation is of critical importance during mammalian spermiogenesis. A set of mRNAs that encode proteins critical to normal sperm formation are synthesized early in the process of male germ cell differentiation and are stored in a repressed state. These mRNAs are subsequently translationally activated during the process of spermatid elongation and maturation. Of note, the t...

This paper provides a selective overview of the past, present and future of pediatric psychopharmacology. The acceptance of medication use in child psychiatry was based on the results of double-blind, placebo-controlled trials documenting the efficacy of drug treatments for attention-deficit/hyperactivity disorder, enuresis, depression, anxiety disorders, obsessive-compulsive disorder and psych...

OBJECTIVE To determine the time course of changes in glucagon and insulin secretion in children with recently diagnosed type 1 diabetes. RESEARCH DESIGN AND METHODS Glucagon and C-peptide concentrations were determined in response to standard mixed meals in 23 patients with type 1 diabetes aged 9.4 +/- 4.6 years, beginning within 6 weeks of diagnosis, and every 3 months thereafter for 1 year....

A growing frustration in clinical medicine is that we are now so busy managing the proliferation of risk factors, “incidentalomas,” and the worried well that we lack the time to care properly for those who are seriously ill. As the definitions of common conditions such as diabetes and kidney disease have expanded and the categories and boundaries of mental disorders have grown, our time and att...

cattle—as concentrated feeds, harvested forages, or a complementary grazing program— accounts for a significant portion of annual production costs in a cattle operation. To optimize productivity of today’s cattle operations, some supplemental nutrients will be required at critical periods during the annual production cycle. However, producers need to avoid unnecessarily compounding this cost by...

Several studies have shown that most climate models underestimate cloud cover and overestimate reflectivity, particularly for the tropical low-level clouds. Here, we analyze characteristics of marine clouds simulated by six models, which provided COSP output within CMIP6 project. CALIPSO lidar observations PARASOL mono-directional reflectance are used model evaluation. It is found “too few, too...