INTRODUCTION We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). MATERIALS AND METHODS Two DM 0.25% formulations [ointment (DM-o) and fatty ointment (DM-fo, water...

Vasomotor symptoms (VMS) are among the most bothersome complaints of postmenopausal women. To date, the most widely studied and effective treatment for VMS is hormone replacement therapy, consisting of estrogen (in women without a uterus) or estrogen plus progestin (in women with a uterus). Traditionally, oral estrogens have been used for treatment. However, over the years, additional estrogen ...

This report describes the efficacy of a novel mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics. Healthy rabbits were subjected to repeated ocular instillations with either conventional gentamicin or ofloxacin or these agents viscosified with the tamarind seed polysaccharide. Administration of vi...

Modem dermatology looks more and more closely in to "old" substances wich proved to be effecti ve and safe. In addition, most of them are much cheaper than the new compounds. Urea is one of the o ld substances which were used more and more often in topica( therapy of dermatoses, either alone or in combination wi th a steroid, anthralin, retinoic acid or salicylic acid. In this paper, biochemist...

Few diseases can claim as many “cures” as have been proposed for warts. In Part 2 of this essay, we describe conventions treatments (topical preparations; cryotherapy, or freezing; surgical removal; and so on), new promising therapies (interferon), and psychological treatment tactics (hypnosis and suggestion). We also highlight some of the more curious folk remedies for warts. Pertinent ISI@ re...

The many benefits of urea as a topical treatment for skin conditions have long been known particularly as an additive to emollient preparations. In podiatry, we have observed a renaissance with an increase in new products coming to market promoted as containing urea. Recent research has begun to unravel its biochemical benefits in treating dry skin conditions. This article reviews the chemical ...

We report the case of a 74-year-old woman who presented with amnesia and positive serum anticholinergic activity (SAA), which disappeared after treatment with the cholinesterase inhibitor donepezil for 1 year. Her only other regular medications were topical glaucoma preparations. We suggest that mental stress, mild cognitive impairment and Alzheimer's disease pathology combined to generate SAA ...

Nystatin is a well-established topical fungicidal agent in the treatment of vaginitis due to Candida albicans (Pace and Schantz, 1956; Chesney, 1956; Rohatiner, 1966). Amphotericin B is effective in a number of systemic fungal infections and can also be used locally, yet few studies have appeared on its value in Candida vaginitis (Jennison, 1958; Stough and Blank, 1958) and none has been design...

The rising prevalence of food allergies poses an BLOCKINincreasingly BLOCKINimportant BLOCKINclinical BLOCKINproblem. BLOCKINPeanut is one of the most potent allergens, and allergic reactions to peanuts may even be fatal. BLOCKINA great proportion of hypersensitive individuals manifest allergic reaction on their first exposure to peanut containing food, pointing to pre-existing sensitiza-tion. ...

CYP: cytochrome P INTRODUCTION Pemphigus foliaceus is a rare autoimmune bullous dermatosis that can be induced by drugs, with variable duration lasting between several weeks and months. Erythematous scaly patches develop on the scalp, face, neck or chest. The use of oral or topical herbal supplements to improve health has increased in the last decades. These preparations may trigger multiple ad...