Kinetic studies conducted under both catalytic and stoichiometric conditions were employed to investigate the reductive elimination of RuPhos (2-dicyclohexylphosphino-2',6'-diisopropoxybiphenyl) based palladium amido complexes. These complexes were found to be the resting state in Pd-catalyzed cross-coupling reactions for a range of aryl halides and diarylamines. Hammett plots demonstrated that...

The cause of the cycle of urinary alcohol levels (UALs) in rats fed ethanol continually at a fixed rate is unknown. Rats were fed ethanol intragastrically at a constant dose for 2 mo, and daily body temperatures and UALs were recorded. Body temperature cycled inversely to UAL, suggesting that the rate of metabolism could be mechanistically involved in the rate of ethanol elimination during the ...

The pharmacokinetics of cyclophosphamide has been evaluated in 15 patients with metastatic breast cancer undergoing high-dose chemotherapy with alkylating agents followed by autologous bone marrow transplantation. Each patient received two courses of chemotherapy: 4 g/m2 of cyclophosphamide by 90-min infusion prior to peripheral blood progenitor cell collection (the first course) and 6 g/m2 of ...

For any extension T of IΣ1 having a cut-elimination property extending that of IΣ1, the number of different proofs that can be obtained by cut-elimination from a single T -proof cannot be bound by a function which is provably total in T .

BACKGROUND The elimination strategy reduced known leprosy prevalence but the detection rate remains high in many countries, including Brazil. The high Brazilian detection rate imposes a limit to the reduction of known prevalence in the short term. The knowledge of time behaviour and spatial distribution of leprosy statistics will contribute to decision making for leprosy control. METHOD The n...

this study was undertaken to identify key elements for obtaining community interest and motivate them to support eliminate malaria in the places that malaria is no longer a perceived threat.sequential explanatory mixed methods research design used to provide more comprehensive evidence research. a questionnaire was developed after reviewing the literature relating to community participation for...