Case Report: A 78-year-old male with relapsed Waldenstrom’s macroglobulinemia following therapy with chlorambucil underwent a five-week course of TBI. The total dose delivered was 1.5 Gy, given as 0.15 Gy twice weekly for ten sessions. During the course of therapy his CD4 cells increased from 637 (cells/mm3) to 808 partly through treatment and then declined to 654 at the completion of therapy. ...

We have previously demonstrated the use of Eclipse fluence optimization to define aperture sizes for a novel aperture modulated translating bed total body irradiation (TBI) technique. The purposes of the present study were to identify, characterize, and correct for sources of error inherent in our previous fluence optimization technique, and to develop a clinically viable fluence optimization m...

Professor Sokrates T. Pantelides ii ACKNOWLEDGMENTS I would first of all like to thank my husband Pierre who has been supportive and patient with me on my journey of attaining a Ph.D. He believed in me even when I did not believe in myself, he listened countless times to my presentations and helped me perfect them. I would also like to thank my parents and my sister Myriam for everything they h...

Modern integrated circuits (IC) operate in environment of various destabilizing factors which have essential influence on the operation of these circuits and often even disturb the normal operation. One of these destabilizing factors is the cosmic radiation, particularly total ionization dose effects (TID). For modern TID tolerant ICs [1-4] design is being done by circuit designers. In this pap...

The total dose effects and SEEs of RT54SX, a new radiation tolerant antifuse FPGA family, are presented. This device family employs a metal-to-metal antifuse technology and a sea-of-modules architecture. Devices manufactured by both 0.6 μm and 0.25 μm technology levels are tested. The devices demonstrate the total dose tolerance better than 100 krad(Si). They are SEL and SEDR immune. For SEU, 0...

Ten patients with active rheumatoid arthritis were given a total dose infusion of iron dextran for anaemia. One had an immediate anaphylactoid reaction; the other nine had a brief exacerbation of arthralgia and joint dysfunction of up to seven days' duration. The erythrocyte sedimentation rate rose by an average of 23 mm. in one hour (Westergren), but this often took longer than seven days to s...