We report the case of a 68-year-old man diagnosed with a nodular melanoma (Breslow depth, 11 mm) in the right submammary region. He had no relevant past history and reported taking no medication, Radiography showed enlarged bilateral axillary, mediastinal, and hilar lymph nodes and multiple bilateral micronodules in the upper and lower lobes of the lung. These nodules showed high uptake, sugges...

I toxic epidermal necrolysis (TEN), a wide layer of skin is peeled and an immature skin layer appears. In a short period, an epidermal necrolysis characterized by scalded appearance of skin due to febrile toxic reaction develops. The mortality rate of this disease is high (20-70%), due to dramatic drug reactions of the skin. The disease resembles mostly to erythema multiforme (EM), Steven Johns...

© 2010 The Authors. doi: 10.2340/00015555-0912 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Toxic epidermal necrolysis (TEN) is a severe episodic mucocutaneous reaction due largely to ingested drugs and/or occasionally to infections. TEN presents as sheets of erythema, necrosis and bullous detachment of the epidermis, with a mortality rate of 30–35% (1). The most common...

The texts discussed here are taken from the Journal of Proceedings of the Linnean Society (vol. III, 1859). The texts appear in this order: Letter dated 30 June 1858 from Charles Lyell and Joshua Hooker presenting the subsequent documents. Extract of an unpublished work on species by Charles Darwin; Extract of a letter from Charles Darwin to A. Gray (Boston), 5 September 1857; Article from Febr...

Sound field methodologies are an essential prerequisite in the development of a basic understanding of toxic cyanobacteria blooms. Sample collection, on-site processing, storage and transportation, and subsequent analysis and documentation are all critically dependent on a sound field program that allows the researcher to construct, with minimal uncertainty, linkages between bloom events and cy...

A lipoid of low molecular weight, isolated from the supernatant fluid of cultures of Pseudomonas pseudomallei, killed mice, but not rabbits, in doses comparable to those of the homologous lipopolysaccharide and also lysed sheep erythrocytes. In rabbits this lipoid failed to elicit primary dermal lesions, to prepare the skin for the local Schwartzman reaction, or to induce antibody

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous responses caused by drugs that characterized widespread necrosis detachment. It is essential to know the risk factors those agents involved in development of this pathology order use them with caution susceptible patients have a high index suspicion.