RATIONALE Treatment of pulmonary nontuberculous mycobacteria, especially Mycobacterium abscessus, requires prolonged, multidrug regimens with high toxicity and suboptimal efficacy. Options for refractory disease are limited. OBJECTIVES We reviewed the efficacy and toxicity of inhaled amikacin in patients with treatment-refractory nontuberculous mycobacterial lung disease. METHODS Records we...

BACKGROUND A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a fixed dose of cisplatin every 3 weeks and to observe the response in Japanes...

Contemporary information on road salt runoff is needed for management of water resources in regions experiencing urbanization and increased road density. We investigated seasonal Cl(-) concentrations among five streams in south-central Indiana that drained watersheds varying in degree of urbanization and ranging in size from 9.3 to 27 km(2). We also conducted acute toxicity tests with Daphnia p...

Sediment toxicity tests are valuable tools for assessing the potential effects of contaminated sediments in dredged material evaluations because they inherently address complexity (e.g., unknown contaminants, mixtures, bioavailability). Although there is a need to understand the chronic and sublethal impacts of contaminants, it is common to conduct only short-term lethality tests in evaluations...

background: in clinical trials of irritable bowel syndrome (ibs), evaluation of treatment efficacy is still mainly subjective.we compared three outcome measures in reflecting response to treatment in a clinical trial of ibs. â  materials and methods: sixty three adult ibs patients participated in a placebo-controlled trial of 10-wk cognitive-behavioral therapy. patients completed the ibs-qualit...

Consensus Regarding new Drug Applications. " The Agency has revised this guidance based on comments it received on the proposed implementation. This approach, designed to facilitate the early stages of pharmaceutical development, is not and ICH consensus position although it is considered to be in general agreement with the ICH position on acute toxicity testing. This guidance was published in ...

the toxicity of 7 herbicides to the three cyanobacteria was tested in this work. the results indicated that: (1) there was a highly significant relationship between dried weight or chlorophyll-a and od680nm for tested cyanobacteria; (2) the toxicity of the tested herbicides with the order from high to low was: photosynthesis-inhibiting > accase inhibitor > protox inhibiting herbicides; (3) the ...

the purpose of the present study was to determine the acute toxicity (lc 50 ) of hgcl 2 and cuso 4 in caspian roach ( rutilus caspicus ) and cuso 4 in caspian kutum ( rutilus kutum ). the caspian roach lc 50 values for hgcl 2 at 24, 48, 72, and 96-hrs of exposure, were 0.64, 0.61, 0.42, and 0.28 mg l -1 , respectively, and for cuso 4 were 11.55, 5.08, 2.49, and 1.47 mg l -1 , respectively. the ...

Most cases of fatal hypothermia are accidental, often in connection with alcoholisation, homelessness, age-related confusedness and others. The phenomenon of paradoxical undressing may be observed. A paradoxical feeling of warmth in the advanced condition of hypothermia leads to the behaviour of undressing, partly or completely. Suicides with intentional hypothermia are rare. Fatal hypothermia ...