The impact of the synthetic glucocorticoid prednjsone on adrenal steroid hormone production was examined using 24-hour urinary steroid hormone profiling. Five women, who were chronically taking low-dose prednisone, were tested, and the relevant literature was reviewed. As expected, adrenal glucocorticoid production, measured by urinary terminal cortisol and cortisone metabolites, was markedly s...

Expression cDNA clones of 1B-1 or 1E-3 subunits coding for human neuronal N(Cav2.2) or R-subtype (Cav2.3) Ca 2 channels, respectively, was combined with 2-b and 3-a Ca 2 channel subunits, and transfected into human embryonic kidney cells for transient expression to determine whether specific types of neuronal voltage-sensitive Ca channels are affected differentially by methylmercury (MeHg) and ...

What is ChatGPT? According to ChatGPT-4 itself, “Generative Pretrained Transformer” software “designed generate text that can answer prompts, engage in conversation, and generally simulate a human-like understanding of wide variety topics.” Can ChatGPT (OpenAI) help emergency physicians? The “thinks” so: “As an artificial intelligence (AI) language model, I certainly assist ways,” saying it be ...

A novel German guideline, VDI 4230, Part 4, has been adopted to provide a standardized protocol for the sampling of freshwater fish for passive biomonitoring with fish as accumulation indicators. The guideline has been designed for multiple purposes, e.g. for the chronological tracking of environmental pollution following hazardous incidents, for the monitoring of the success of regulatory meas...