BACKGROUND The accumulation of larger and protein-bound toxins is involved in the uraemic syndrome but their elimination by dialysis therapy remains difficult. In the present study, the impact of the albumin permeability of recently introduced advanced high-flux dialysis membranes on the removal of such substances was tested in haemodialysis and online post-dilution haemodiafiltration. METHOD...

Professor Department of Computer Science, Avinashilingam Deemed University, Coimbatore -43. Tamilnadu, India. Abstract: Mycotoxins are toxic substances produced mostly as secondary metabolites by fungi that grow on seeds and feed in the field, or in storage. The food-borne Mycotoxins likely to be of greatest significance for human health are Aflatoxin and Fumonisins. Chili pepper is also affect...

OBJECTIVE Sphingosylphosphorylcholine (SPC) is an important lipid mediator that has been implicated in vascular disease. As it has not been studied in the pulmonary circulation, we examined its mechanisms of action in rat small intrapulmonary arteries (IPA). METHODS IPA were mounted on a myograph for recording tension and intracellular Ca2+ concentration ([Ca2+]i). Ca2+ sensitisation was exam...

The ability of the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) to promote the release of the organic osmolyte taurine in response to hypoosmotic stress has been examined. Incubation of SH-SY5Y neuroblastoma cells under hypoosmotic conditions (230 mOsM) resulted in a time-dependent release of taurine that was markedly enhanced (3-7-fold) by the addition of mic...

Background and Objectives: This study aimed to identify the presence of microorganisms in aesthetic environment assess professionals’ knowledge about relevant infection prevention measures, considering importance issue lack area. Methods: A total 100 clinics that perform minimally invasive procedures Porto Alegre (RS), Brazil, were visited. Procedures such as botulin-toxin, dermal fillers, coll...

introduction: clostridium difficile is the etiologic agent of several infections such as pseudomembranous colitis in human. these diseases are frequently associated with antibiotic useage but many infections with this organisms are seen without antibiotic administration. in addition it is believed that clostridium difficile is one of the most important bacteria involved in acquired hospital inf...

Intoxication by cytolethal distending toxin depends on assembly of CdtB, the active A component of this AB toxin, with the cell surface-binding (B) component, composed of the CdtA-CdtC heterodimer, to form the active holotoxin. Here we examine the cell surface binding properties of Escherichia coli-derived CdtA-II (CdtA-II(Ec)) and CdtC-II(Ec) and their capacity to provide a binding platform fo...

BACKGROUND Degradation of the toxic compounds generated in the harsh pretreatment of lignocellulose is an inevitable step in reducing the toxin level for conducting practical enzymatic hydrolysis and ethanol fermentation processes. Various detoxification methods have been tried and many negative outcomes were found using these methods, such as the massive freshwater usage and wastewater generat...

Seeds of the castor bean plant Ricinuscommunis L (CB) contain ricin toxin (RT), one of the most poisonous naturally-occurring substances known. Ricin toxin, a water-soluble glycoprotein that does not partition into the oil extract, is a ribosome-inactivating toxin composed of two chains, labeled A and B. Severity of the toxicity varies depending on the route of exposure to the toxin. Inhalation...

Clostridium perfringens is a gram-positive, obligate anaerobic bacterium, which is widely distributed in the environment. C. perfringens is subdivided to 5 groups (types A to E), based on its four major toxin (alpha, beta, epsilon and iota). C. perfringens type B beta toxin causes inflammation and bloody necrotic enteritis. Type B related enterotoxaemia is a major problem of veterinary sciences...