In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge resources. Repurposing know-how, a strategy that capitalises previously acquired information expertise, has emerged as powerful approach to accelerate processes, often at fraction of the costs de novo developments. For 80 years, collaborating within network partnerships, Swis...

The authors investigated whether different types of aggression relate to the A779C tryptophan hydroxylase (TPH) polymorphism and to serotonergic activity in volunteers. A factor analysis of the Buss-Durkee Hostility Inventory yielded 2 factors representing Neurotic Hostility (NH) and Aggressive Hostility (AH). The authors used a neuroendocrine challenge with Citalopram in 48 volunteers and incr...

In situ bioremediation of oily sludge-contaminated soil by biostimulation of indigenous microbes through adding manure was conducted at the Shengli oilfield in northern China. After bioremediation for 360 days, total petroleum hydrocarbon (TPH) content was reduced by 58.2% in the treated plots compared with only 15.6% in the control plot. Moreover, bioremediation significantly improved the phys...

Three psychoactive amphetamine congeners were evaluated for their ability to cause long-term changes in several neurochemical parameters indicative of central serotonergic function. Two weeks after multiple doses (10 mg/kg) of 3,4-methylenedioxyamphetamine (MDA) or its N-methylated derivative, 3,4-methylenedioxymethamphetamine (MDMA), selective and dramatic decreases were observed in regional b...

This study was carried out for remediation of drill cutting soil from two oil field sites in Kurdistan Region Iraq. nanotechnology implemented. Heavy metal (Pb, Cd, Cr, Ni and petroleum hydrocarbons (C8-C24, C24-C40, TPH) were analyzed before after soil. The experiment designed. results indicate that the concentration heavy metals (Ni, Cd Cr) within normal range except Pb. result showed removal...

Leakages of oil products derived from petroleum can affect the environment, even causing risks to human. In order to study all the substances that usually are found in a petroleum leakage, it becomes interesting to apply the study to the Total Petroleum Hydrocarbons (TPH) fractions which have similar physico-chemical properties. The purpose of this paper is to perform a suitable risk specific s...

This study evaluated the effects of aeration (constant aeration, intermittent aeration and a lack of aeration) and hydraulic retention time (HRT) (2, 3 and 4 days) on a continuous process with cell recycling, using chitosan as a natural coagulant for the sedimentation of a C1 mixed culture. This culture was used for the biodegradation of hydrocarbons present in the effluent contaminated with di...