G.S. 2989 Hcl (Pfizer) is a new tetracycline derivative without any generic name. In a cinico-cytological study by Nema, Nath, Bal, and Shukla (1964) on 48 trachomatous cases treated by G.S. 2989 Hcl (025 per cent. in oil) the antibiotic was found quite effective against trachoma and associated bacterial conjunctivitis. It was observed that the drug could produce 66-7 per cent. cure of trachoma...

A random sample of 9548 Palestinian Arabs living in the West Bank and Gaza Strip was identified, and 9054 (95.7%) were examined. Particular attention was directed to reduced visual acuity (VA) and its cause and to trachoma. Low visual acuity was defined as less than 6/18 in both eyes and binocular blindness as a VA less than 3/60 in both eyes. The overall incidence of low VA was 6.8% and of bin...

Tear immunoglobulin concentrations have been measured in 100 healthy people and 62 patients in different stages of trachoma. In healthy people the average IgA level was 27f8 mg/100 ml. There was no significant difference in the IgA level in various age groups and between the sexes. IgG was detected in 92 samples, and it was less than 1 mg/100 ml. IgM in tears was detected in only one sample. Ig...

Mass antibiotic treatment and facial cleanliness are central to WHO's strategy for the elimination of blindness caused by trachoma. Recent studies have highlighted the heterogeneous response of communities to mass treatment and the complex relation between infection with Chlamydia trachomatis and clinical disease. It is important to be able to explain these findings to predict and maximise the ...

Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted infections (STIs). We used comparative genomics of the family Chlamydiaceae to select conserved housekeeping genes for C. trachomatis multilocus sequencing, characterizing 19 reference and 68 clinical isolates from 6 continental/subcontinental regions. There were 44 sequence types (ST). Identical STs for STI i...

AIMS To determine if macrolide resistant Streptococcus pneumoniae will be a major concern in areas that receive annual mass azithromycin distributions for trachoma. METHODS A cross sectional survey was conducted of nasopharyngeal S pneumoniae isolates for susceptibility to azithromycin 1 year after administering a single dose of azithromycin to treat trachoma in a village in Nepal. RESULTS ...

THE first convincing isolation of the trachoma virus was made by T'ang, Chang, Huang, and Wang (1957) using embryonate eggs: their findings were confirmed by Collier and Sowa (1958), who also showed that clinical trachoma followed inoculation of a human volunteer with isolated virus. Isolation of the virus from patients with trachoma in Australia has not previously been reported although the di...

This study described the pattern of trichiasis, active trachoma and trachoma risk factors in 9 governorates of Yemen plus Socotra Island, using a rapid assessment during October and February 2004. A total of 3169 children aged 1-9 years were examined in a central meeting point or at home. Active trachoma was found in a high percentage of children in Al-Jawf, Mareb and Shabwah governorates and t...

THE first convincing isolation of the trachoma virus was made by T'ang, Chang, Huang, and Wang (1957) using embryonate eggs: their findings were confirmed by Collier and Sowa (1958), who also showed that clinical trachoma followed inoculation of a human volunteer with isolated virus. Isolation of the virus from patients with trachoma in Australia has not previously been reported although the di...