To observe the effect of Huazhuojiedu medicated serum on the proliferation and activation of hepatic stellate cells, as well as the expression of PI3K and p-Akt in rats, and to explore the underlying mechanism of Huazhuojiedu prescription against hepatic fibrosis. Hepatic stellate cells harvested from rats were resuscitated and subcultured, followed by the intervention of Huazhuojiedu equivalen...

introduction: transforming growth factor-beta 1 (tgf-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of ischemic stroke (is), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509c/t tgf-β1 gene polymorphism has been found to be assoc...

Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone (DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) isoflavones inhibits transforming growth factor (TGF)-β-induced androgenicity. Mechanisms controlling those activities were explored. Three hyd...

silver salts and nanosilver (ns) are the common antimicrobial used in the treatment of chronic wounds, so they are important to assess their dermal toxicity. therefore, in this study, the possible dermal toxicity of ns particles and silver nitrate (agno3), was tested by determining the serum level of transforming growth factor-β1(tgf-β1) and study on of mouse skin tissue. in this study, 30 balb...

The transforming growth factor β1 (TGF-β1) belongs to a family of structurally related polypeptide factors. TGF-beta plays an important role in the pathobiology of invasion of malignant gliomas. The objective of the present study was to investigate the impact of TNF-α converting enzyme (TACE/ADAM17) signaling on the process of TGF-β1-stimulated migration and invasion of T98G glioma cells. We fo...

Platelets play a role in tumor angiogenesis and growth and are the main transporters of several angiogenesis regulators. Here, we aimed to determine the levels of angiogenesis regulators and epithelial-mesenchymal transition factors sequestered by circulating platelets in breast cancer patients and age-matched healthy controls. Platelet pellets (PP) and platelet-poor plasma (PPP) were collected...

Objective: This study’s aim was to assess the efficacy of topical Binahong (Anredera cordifolia (Ten.) Steenis) leaf ethanolic extract administration on serum transforming growth factor-beta 1 (TGF-β1) in infected wounds.
 Methods: An experimental study, vivo, conducted Biotechnology Laboratory and Animal House, Faculty Medicine, Universitas Sriwijaya, Palembang, from July September 2020. ...

The critical involvement of TGF-β1 (transforming growth factor-β1) in DN (diabetic nephropathy) is well established. However, the role of CTGF (connective tissue growth factor) in regulating the complex interplay of TGF-β1 signalling networks is poorly understood. The purpose of the present study was to investigate co-operative signalling between CTGF and TGF-β1 and its physiological significan...

objective(s):we investigated the influence of genetic variation of the transforming growth-factor alpha (tgfa) locus on the relationship between smoking and oral clefts. materials and methods:in this study 105 iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...