Aim/Purpose: In this paper we propose an ecosystem for translational learning that combines core principles with a multilevel construct embraces the tenets of research, namely, teaming, translating, and implementing. The goal is to argue knowledge sciences essential at individual, team, organizational levels in science enterprise. Background: two decades can now call era health medicine have no...

Composite steel/concrete beams may buckle in hogging bending regions. As the top flange of I-beam in that arrangement is restricted from any translational deformation and twist, the web will distort during buckling presenting a phenomenon often described as restricted distortional buckling. There are limited studies available in the literature of restricted distortional buckling of composite st...

The natural frequencies and mode shapes of pneumatic tires are predicted using a geometrically accurate, three-dimensional finite element modeling. Tire rubber materials and cord layers are represented independently using “shell element” available in COSMOS. The effects of some physical parameters such as the inflation pressure tread pattern, thickness of belts and ply angles to the natural ...

The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. Trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( Trp-Cys-Gly-Pro- Cys-Lys-). Different factors are involved in the regulation of T...

High-throughput RNAi screening identifies a role for TNK1 in growth and survival of 1 pancreatic cancer cells 2 3 Meredith C. Henderson, Irma M. Gonzales, Shilpi Arora, Ashish Choudhary, Jeffrey M. 4 Trent, Daniel D. Von Hoff, Spyro Mousses, David O. Azorsa 5 6 Clinical Translational Research Division, The Translational Genomics Research Institute, 7 Phoenix, AZ, 85004, USA 8 Pharmaceutical Gen...