objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...

the initial experience concerning the use of magnetic resonance imaging in 94 patients who had sustained chronic cord injury showed its specific advantages over traditional imaging modalities. a variety of 84 cord abnormalities were identified including myelomalacia in 47%, cord cysts in 37%, focal atrophy in 11 % and cord transection in 5%. canal stenosis was seen in twenty-five patients, elev...

INTRODUCTION Traumatic brain injury (TBI) is one of the main causes of morbidity and mortality in young trauma patients with resultant multi-organ effects. Hypopituitarism following TBI can be debilitating and life threatening. TBI which causes hypopituitarism may be characterized by a single head injury, such as from a motor vehicle accident, or by chronic repetitive head trauma, as seen in co...

Abstract Traumatic brain injury (TBI) is a multistep interaction of antigens, cytokine-mediated humeral, and cellular immune reactions. Because the limitations clinical radiological evaluation in TBI, there has been considerable advancement toward need for developing biomarkers that can predict severity TBI. Blood-based hold potential to absence intracranial thus decrease unnecessary computed t...

A 53-year-old male with history of traumatic brain injury (TBI) presented localized dissociative amnesia following a second head injury. While memory loss due to TBI is present in the literature, presentations this type are very rare. Although fully independent activities daily living, patient demonstrated severe deficits visual and processing speed upon neurocognitive evaluation. Effort testin...

OBJECTIVE To correlate neuropsychological outcome in patients after severe traumatic head injury, with neurophysiological and neuroradiological data collected during the intensive care unit (ICU) period of care. METHODS Patients admitted to Waikato Hospital ICU with severe traumatic head injury were studied. Respiratory difficulty at the accident site, admission Glasgow Coma Score (GCS), anat...