A predominant population of mucosal nerves in the mammalian gastric body has been known to contain large amounts of gastrin-releasing peptide (GRP). The present immunohistochemical study demonstrates the depletion of GRP immunoreactivity from nerves in the oxyntic mucosa of rats with ulcers induced by restraint plus water immersion. Depletion of GRP occurred in a major part of the nerves after ...

Case Report We confirmed the Muckle-Wells syndrome phenotype of CAPS by NLRP3 genetic testing in a three generation family of Turkish Jewish origin, previously diagnosed with familial Behcet disease due to the presence of mucosal ulcers in several family members with the finding of the HLA-B51 antigen in at least one family member. Eight family members including a deceased grandfather, 4 of his...

nystatin oral suspension is a safe firstline therapy; fluconazole is more effective (strength of recommendation [sor]: B, 1 small randomized controlled trial [rCT]) but has not been approved by the Food and Drug Administration (FDA) for use in immunocompetent infants. Miconazole oral gel is also more effective than nystatin suspension, but is not commercially available in the united states (sor...

The defects of mucosal surfaces of the face, either congenital, traumatic, or postoperative, have been prominent subjects of plastic surgery. Local skin flaps and free flaps have been used to repair these defects. Because the face is the most vascularized portion of the body, skin flaps in this area have a great chance for viability. Buccal mucosa also shares the same feature of vascularity and...

BACKGROUND AND PURPOSE The purpose of this study was to review CT imaging findings of soft tissue mucosal ulceration in patients following radiation treatment for head and neck malignancies and to correlate these with patient outcomes. MATERIALS AND METHODS The CT examinations in 20 patients with soft tissue ulceration after radiation therapy for treatment of head and neck cancer were reviewe...

Chronic ulcerative stomatitis (CUS) is a mucocutaneous disorder which is characterised by persistent oral mucosal ulceration. The clinical appearance is often reminiscent of oral lichen planus (OLP) leading to erroneous diagnoses. The immune mediated inhibition of the CUS protein (CUSP) is implicated in the pathogenesis of CUS. CUSP acts as an anti-apoptotic protein and when its action is preve...

The goal of this study was to gather more clinical information about the relationship between Helicobacter species and gastric ulceration in horses. Twenty seven privately owned patients were selected for the clinical study. All horses were gastroscopically examined and biopsies were taken from the glandular mucosa. Stomach biopsies were examined using a PCR assay specific for Helicobacter pylo...

Dermatomyositis (DM) patients with autoantibodies against nuclear matrix protein 2 (NXP2) have heterogeneous outcomes, some experiencing a severe disease course. In addition to documented features (e.g., calcinosis cutis, dysphagia, myalgia), subset of develop cutaneous and/or mucosal ulcers. We sought determine if ulceration, along other key clinical features, is associated severity. conducted...

AIMS To determine the incidence of ocular trauma and corneal ulceration in the district of Bhaktapur in Kathmandu Valley, and to determine whether or not topical antibiotic prophylaxis can prevent the development of ulceration after corneal abrasion. METHODS A defined population of 34 902 individuals was closely followed prospectively for 2 years by 81 primary eye care workers who referred al...

Objective: To evaluate the vulnerability of gastric mucosa to ulceration in non-insulin-dependent diabetes mellitus (NIDDM) rats vis-à-vis the protective effects of the methanolic extract of Pterocarpus marsupium heartwood (PMS, an antidiabetic herbal plant). Material and Methods: NIDDM was produced in 5-day-old rat pups by administering streptozotocin (70 mg/kg, i.p). The animals showing blood...