background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

objective(s) wound licking has been shown to advance wound healing among humans and many other animals. the present study evaluates the licking effects on healing of skin wound in rats. materials and methods twenty four rats were assigned to 4 different groups randomly and two 3 cm longitudinal full thickness incisions were made on each dorsal and ventral side of rats. the ventral incisions wer...

Due to the range of its constituents, colostrum has been considered as a supplement for various diverse purposes. This study was conducted to examine the effect of supplementary bovine colostrum on serum malondialdehyde (MDA), antioxidant activity (AOA) and glucose in a diabetic rodent model. Sixty male Wistar rats were divided into 10 groups of six rats each for 40 days as follows: non-diabeti...

The present study was conducted to ascertain the estrogenic effect of Zhuang Medicated Thread Moxibustion (ZMTM) and explore its time-sensitive impact on estradiol (E2) in female perimenopausal rats. 40 rats were randomized into four groups: control, model, ZMTM, acupuncture groups. syndrome induced last three groups with a daily subcutaneous dose 80 mg/kg 4-vinylcyclohexene diepoxide for 15 da...

background and objective: hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. this study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (stz)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. materials and methods: this study was conducted on 40 male...

objective(s): bone marrow-derived mesenchymal stem cells (bm-mscs) potentials make them appropriate for cell therapy including ability of differentiation and release of anti-inflammatory cytokines and growth factors secreta. for treatment of azoospermia to induce proliferation and differentiation of germ cells, mscs transplantation has been introduced. the aim of the present experimental case-c...

background: medicinal plants with biologically active components such as antioxidant and antidiabetic are useful sources of novel therapeutics. in iran, traditionally believed that the aqueous extract of berberry fruit (berberis integerima f.) improved health, especially in people with diabetes. objective: in this study, in vitro phytochemical and antioxidant activities of b. integerrima and b....