High-dose methylprednisolone pulse therapy is widely used in patients with severe COVID-19. This known to have sufficient clinical effectiveness, but the optimal administration method not known. In this study, we assessed deterioration of oxygenation after COVID-19 according disease severity (oxygen requirement) at initiation therapy. Ninety-nine who received Saitama Medical University Hospital...

AIMS To characterize temporal trends in the selection and timing of first-line pharmacotherapy among older patients with Type 2 diabetes. DESIGN AND METHODS We studied five population-based cohorts every 3 years, from 1994 to 2006. In each of those years, we identified all subjects aged 66 years or older newly diagnosed with diabetes and determined the initial glucose-lowering drug and the ti...

The optimum time to start antiretroviral therapy (ART) in a HIV infected patient receiving antituberculosis therapy (ATT) is unknown. 2 Concurrent treatment of tuberculosis (TB) and HIV is complicated by poor adherence from high pill burden, overlapping toxicities, pharmacokinetic drug–drug interactions and risk of immune reconstitution inflammatory syndrome (IRIS). The risk of disease progress...

Thirty two infants born to mothers taking methadone and 32 matched controls were studied to determine the incidence, timing, and frequency of persistence of withdrawal signs in infants born to maternal methadone users. Twelve (37%) infants received treatment for symptoms of withdrawal. The median length of time from birth to initiation of treatment was 23 hours (range 15-64 hours), the median l...

In their article recently published in the Journal, Love et al. (1) present provoking evidence that in a cohort of Vietnamese premenopausal breast cancer patients the timing of initiation of adjuvant hormone therapy (oophorectomy + tamoxifen) during the luteal phase of the menstrual cycle improves 5-year disease-free and overall survival. These data add fuel to the fire of the ongoing controver...

BACKGROUND Phenylketonuria (PKU) - the most common inherited disorder of amino acid metabolism, identified in Russia by neonatal screening. The results of dietary treatment demonstrate a positive effect. However, the quality of PKU patients life remains unknown. OBJECTIVE The aim of the study was to assess the quality of PKU children life in comparison with their healthy peers, also depending...

We have developed a new approach to characterize allele-specific timing of DNA replication genome-wide in human primary basophilic erythroblasts. We show that the two chromosome homologs replicate at the same time in about 88% of the genome and that large structural variants are preferentially associated with asynchronous replication. We identified about 600 megabase-sized asynchronously replic...