PURPOSE An oil in water emulsion of 0.01% all-trans-retinoic acid (tretinoin) was prepared and clinically evaluated in dry eye patients. METHODS The ophthalmic emulsion consisted of 10% of arachis oil and 90% of the hydrogel of Carbopol 940. To evaluate retinoic acid emulsion clinically, a placebo-controlled, open-labeled, randomized study was performed with 22 dry-eye patients. Symptoms were...

TOPIC: Pulmonary Manifestations of Systemic Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Acute Promyelocytic Leukemia Differentiation Syndrome (DS) also known as Retinoic Acid (RAS) is a potentially lethal complication All-Trans (ATRA) treatment. Symptoms are initially nonspecific from dyspnea, weight gain, fever and weakness. Major findings seen in DS includes bilateral in...