The present feature article describes the different organocatalytic routes for the synthesis of substituted 1,2,3-triazoles. This methodology has recently gained much attention due to its many advantages like high regioselectivity, substrate scope, high yields, and access to novel molecules. The review is divided into 4 different sections based on the active intermediate of the triazole synthes...

The functionalizability and conformational properties of azidoproline (Azp)-containing collagen model peptides (CMPs) were studied. The results show that (4R)Azp has a similar stabilizing effect on the collagen triple helix as (4R)hydroxyproline and that functionalized CMPs are readily accessible by "click" chemistry. The resulting triazole-functionalized CMPs form stable triple helices, demons...

In the title compound, C(10)H(11)N(3)O(2), the triazole ring has a dihedral angle of 11.55 (2)° relative to the benzene ring. The crystal packing is stabilized by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds, and by weak π-π stacking inter-actions [centroid-to-centroid distance = 3.545 (3) Å].

Dimroth rearrangement in a thiadiazole—triazole system was first observed by Kindt—Larsen and Pedersen [1] when 5-mercapto-l-phenyl-l,2,3-triazole was formed from 5-anilino-l,2,3-thiadiazole. A similar rearrangement has been ob­ served to take place with 4-substituted 5-amino-l,2,3-thiadiazoles [2] and 4-acyl-5-arylamino-l,2,3-thiadiazoles [3]. In the present work the kinetics of the rearrangem...

The mode of action for the reproductive toxicity of some triazole antifungals has been characterized as an increase in serum testosterone and hepatic response, and reduced insemination and fertility indices. In order to refine our mechanistic understanding of these potential modes of action, gene expression profiling was conducted on liver and testis from male Wistar Han IGS rats exposed to myc...

The title compound, C(19)H(16)N(4), is one of the few known 3,7-diaryl-1,2,4-triazolo[4,3-c]pyrimidines. The triazolopyrimidine unit is essentially planar (r.m.s. deviation = 0.048 Å). The phenyl ring and the heterocyclic core subtend a dihedral angle of only 15.09 (6)°, whereas the m-tolyl ring is twisted by 71.80 (6)° out of the plane of the triazole ring. Two C-H⋯N hydrogen bonds and π-π sta...

In the title compound, C(8)H(8)N(4), the dihedral angle between the triazole ring [maximum deviation = 0.003 (1) Å] and the benzene ring is 34.57 (7)°. In the crystal, mol-ecules are linked into sheets lying parallel to the ac plane via inter-molecular N-H⋯N and C-H⋯N hydrogen bonds. Aromatic π-π [centroid-centroid distance = 3.6750 (8) Å] stacking and N-H⋯π inter-actions are also observed.

In the title mol-ecule, C(13)H(10)N(4), the dihedral angle between the triazole ring and the naphthalene ring system is is 56.1 (2)°. In the crystal, mol-ecules are connected by weak C-H⋯N hydrogen bonds into chains along [100]. A short intra-molecular C-H⋯N contact is also observed.

a new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air...

In the title compound, C(11)H(9)F(2)N(3)O(2), the triazole ring is planar, with an r.m.s. deviation of 0.0048 Å, and makes a dihedral angle of 77.3 (1)° with the benzene ring. In the crystal, weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds link the mol-ecules into chains along the b axis.