Based on the crystal structure of LeuTAa, a bacterial homologue to the Na+/Cl--dependent neurotransmitter transporters (SLC6 family) from Aquifex aeolicus, it was proposed that inhibitors of the serotonin and norepinephrine transporters (i.e., tricyclic antidepressants, TCAs) bind in the outer vestibule of the transporter and thus occlude access of the substrate to the substrate binding site. T...

anxiety is both a normal emotion and a disorder which can cause profound distress and functional impairment. the range of treatments available for anxiety has improved substantially in the last 20 years. this has in part been due to improved understanding of the neurobiological mechanisms underlying anxiety. Guidelines are available for the treatment of the various anxiety disorders; selective ...

Die starke Stimulierung der Synthese möglicher­ weise saurer Kernproteine unter Insulin läßt sich mit diesen Befunden in Einklang bringen. Die Aufgaben der sauren Kernproteine bei der Regulation auf Genebene sind in zunehmendem Maß Gegenstand der Spekulation. Einige Polyanionen, besonders saure Proteine, Polyäthylensulfonat und RNA 20-23, steigern die endogene RNA-Synthese von isoliertem Chroma...

OBJECTIVE To describe, analyze, and interpret patterns of psychotropic drug prescribing in new psychiatric patients attending psychiatric outpatient clinics in the Caribbean island of Trinidad. DESIGN AND METHODS This was a cross-sectional study of psychotropic drug prescribing by psychiatrists for 132 new psychiatric outpatients who were seen at the outpatient clinics surveyed and who were e...

The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or other anticholinergic agent. Following the Naranjo algorithm, this case report describes a probabl...

background: this study compares the efficacy of fluoxetine (serotonin-selective reuptake inhibitors-ssri) with doxepin (tricyclic antidepressants –tcas- antihistaminic) in treatment of irritable bowel syndrome (ibs). methods: this randomized clinical trail recruited 200 patients who had referred to kermanshah imam reza hospital during the period 2006-7. all the patients had been diagnosed with ...

The development of newer classes of antidepressants and second-generation antiepileptic drugs has created unprecedented opportunities for the treatment of chronic pain. These drugs modulate pain transmission by interacting with specific neurotransmitters and ion channels. The actions of antidepressants and antiepileptic drugs differ in neuropathic and non-neuropathic pain, and agents within eac...