Abstract Background This study was established to assess cysteamine’s cytotoxic effect alone and in combination with various intracanal medications on fibroblast cells, because the biocompatibility of medication is considered one main factors that affect selection specific for usage near vital periodontal tissues. Methods All tested were prepared a solution form. Cysteamine preparation at 200 m...

Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...

aim: the increasing prevalence of antibiotic-resistant bacteria is a major health-care problem worldwide. who recommends did (daily defined dose/ 100 inhabitant /day) as a standard tool for measurement of antibiotic consumption. since there was not any information regarding the antibiotics usage pattern in the north of iran, the aim of this study was determine this in our centre.method: this cr...

eradication rate of helicobacter pylori using low dose furazolidone in triple & quadruple therapies versus metronidazol in triple therapy in du patients

OBJECTIVE Helicobacter pylori (HP) is the world's most common infectious agent. Despite conventional therapy consisting of proton pump inhibitor (PPI), amoxicillin (AMO) and clarithromycin (CLA), approximately half of the patients remain infected. We compared the PPI-based triple therapy with quadruple treatment (BPMT) including bismuth citrate (BS), PPI, metronidazole (MET) and tetracycline (T...

Filarial parasites can be targeted by antibiotic treatment due to their unique endosymbiotic relationship with Wolbachia bacteria. This finding has led to successful treatment strategies in both, human onchocerciasis and lymphatic filariasis. A 4-6 week treatment course using doxycycline results in long-term sterility and safe macrofilaricidal activity in humans. However, current treatment time...

Surgically induced duodenal reflux results in cancer development in the rat esophagus. One proposed mechanism of carcinogenesis relies on the production of carcinogens in the presence of bacterial overgrowth. Against this background, intestinal microflora in the rat jejunum was analyzed before and after reflux-inducing surgery. Total gastrectomy and esophagojejunostomy were performed on Sprague...

AIMS Mounting evidence suggests infection, specifically Chlamydia pneumoniae, plays a role in atherosclerosis. We tested whether antibiotic treatment with the macrolide roxithromycin improves clinical outcome in patients with acute non-Q-wave coronary syndromes. Preliminary reports revealed a reduction in events in the roxithromycin group at 30 days. We now report the long-term follow-up result...

Background: Helicobacter pylori infection infects approximately 50% of the world’s population, and is associated with significant morbidity and mortality. H. pylori infection is associated with large expenditures for diagnostic testing and prescription medication. Summary: The C13-urea breath test remains the non-invasive test with the highest sensitivity and specificity, and is the test-of-cho...

Most Helicobacter pylori strains are susceptible to tetracycline, an antibiotic commonly used for the eradication of H. pylori. However, an increase in incidence of tetracycline resistance in H. pylori has recently been reported. Here the mechanism of tetracycline resistance of the first Dutch tetracycline-resistant (Tet(r)) H. pylori isolate (strain 181) is investigated. Twelve genes were sele...