Background: Triple-negative breast cancers (TNBC) have a more aggressive course and are associated with poorer prognosis in comparison with other subtypes of breast cancer. One of the most common subtypes of TNBC is basal-like. The aim of this study was to investigate clinicopathological characteristics and clinical course of TNBC in Iranian women and compare them with other studies. Subjects a...

Breast cancer is a complex disease and one of the main causes of cancer-related mortality in women worldwide. In case of approximately 15% of all breast cancers, three markers i.e. estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptors-2 (HER2) are not express, and is commonly termed as triple-negative breast cancer (TNBC). Particularly, TNBC is associa...

MOTIVATION Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer group, and identification of molecular subtypes is essential for understanding the biological characteristics and clinical behaviors of TNBC as well as for developing personalized treatments. Based on 3,247 gene expression profiles from 21 breast cancer data sets, we discovered six TNBC subtypes from 587 TNBC sampl...

Triple negative breast cancer (TNBC) is a heterogeneous disease comprehending different orphan breast cancers simply defined by the absence of ER/PR/HER-2. Approximately 15%-20% of all breast cancers belong to this phenotype that has distinct risk factors, distinct molecular features, and a particular clinical presentation and outcome. All these features will be discussed in this review. The ri...

Triple negative breast cancer (TNBC) is the most aggressive subtype of cancer, with limited treatment options and high rates recurrence metastasis due to lack specific therapeutic targets. The incidence bone metastases brain also high. They are more likely relapse have a poor long-term prognosis. tumor microenvironment (TME) consists cells, variety mesenchymal cells an extracellular matrix, whi...

Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown to play a role in various cancers, including breast cancer. However, FABP5 and its role in triple negative breast cancer (TNBC) have not been studied. We show FABP5 protein expression correlates with TNBC, high grade tumors, and worse disease-free survival in a tissue microarray containing 423 breast ca...

Triple-negative breast cancer (TNBC) represents a subtype of breast cancer characterized by high aggressiveness. There is no current targeted therapy for these patients whose prognosis, as a group, is very poor. Here, we report the synthesis and evaluation of a potent antitumor agent in vivo for this type of breast cancer designed as a combination of quinone/cannabinoid pharmacophores. This new...

MicroRNA (miR)‑29b has been reported to play a controversial role in breast cancer, particularly triple‑negative cancer (TNBC). Based on our previous data revealing that the PU.1‑mediated expression of miR‑29b cells from acute myeloid leukemia is sustained by Vav1, potential this multidomain protein modulating levels tumor cells, which Vav1 ecstopically expressed and shows nuclear accumulation,...

UNLABELLED Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer commonly resistant to therapeutics that have been successful in increasing survival in patients with estrogen receptor-positive (ER(+)) and HER2(+) breast cancer. As such, identifying factors that contribute to poor patient outcomes and mediate the growth and survival of TNBC cells remain importa...

background: triple-negative breast cancer (tnbc) carries a poor prognosis and therapeutic options are limited to date. the aim of this study was to investigate to what extent the epidermal growth factor receptor (egfr), vascular endothelial growth factor receptor 2 (vegfr2), hypoxia inducible factor-1 alpha (hif-1α) and insulin-like growth factor-1 receptor (igf-1r) are expressed in tnbc and to...