BACKGROUND High-sensitivity cardiac troponin assays will augment the frequency of increased results, making important the determination of reference change values to distinguish acute from chronic increases. We assessed short- and long-term biological variability of cardiac troponin T (cTnT) in healthy subjects with a novel high-sensitivity (hs) assay. METHODS We collected blood from 20 healt...

BACKGROUND Over the past decade, a large body of evidence has emerged demonstrating the prognostic significance of troponin as well as its use in tailoring therapeutic interventions. Little is known, however, regarding the association of troponin status with guideline-based therapies in older patients with acute myocardial infarction (AMI). METHODS A nationwide sample of eligible Medicare ben...

elevated during chemotherapy, a phenomenon that was correlated to the extent of the impairment of left ventricular systolic performance. Some other similar studies have provided evidence for a correlation between higher troponin levels and low left ventricular ejection fraction. Cardinale et al. (2) determined troponin I levels before, during, immediately after, and one month after chemotherapy...

BACKGROUND Identifying hospitals that are both early and consistent adopters of high-value care can help shed light on the culture and practices at those institutions that are necessary to promote high-value care nationwide. The use of troponin to diagnose acute myocardial infarction (AMI), and not to test for myoglobin or creatine kinase-MB (CK-MB), is a high-value recommendation of the Choosi...

1 Fröhlich GM, Leistner DM. Open Heart 2017;4:e000590. doi:10.1136/openhrt-2017-000590 High-sensitivity troponin is—per definition—highly sensitive to detect all sorts of myocardial injury. This does not necessarily mean that permanent damage has been done to the myocyte. It is known that the troponin level may well be elevated after exceptional physical exercise, like in marathon runners. Of c...

I n 2000, the European Society of Cardiology and the American College of Cardiology presented new diagnostic criteria for myocardial infarction (MI) which placed a greater emphasis on cardiac markers by stating that any elevation in cardiac troponin T (cTnT) or cardiac troponin I (cTnI) above the 99th centile of normal was sufficient to diagnose a MI. Recent studies since then have shown that t...

The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an important mechanism for regulating cardiac contractility. cTnC contains two EF-hand domains (the N and C domain of cTnC, cNTnC and cCTnC) conne...

BACKGROUND Myocardial infarction (MI) is diagnosed by the finding of a single cardiac troponin value above the 99th percentile and a significant time-dependent change in cardiac troponin concentration. The aim of this study was to determine the 90-min and weekly biological variations, the reference change value (RCV), and the index of individuality (II) of high-sensitivity cardiac troponin T (h...

the registry of myocardial infarctions (mi registry) is a national registry in iran that collects and reports the data on myocardial infarctions. its main advantage is that it covers the whole country and is mandatory for hospitals to register the mi cases in it. then, the qualified individuals at the provincial and national levels can get intended reports and make appropriate decisions. such r...