Background Considering the highest adverse events risk (predominantly infectious disease and osteoporosis) of glucocorticoids (GCs), EULAR recommended a short-term use GCs with rapid tapering as soon clinically feasible in rheumatoid arthritis (RA) patients. Although prednisone dose less than or equal to 7,5 mg/die is considered more safety, complete discontinuation would be desirable. Few data...

Profiling the vertical atmospheric structure for typhoons remains challenging. Here, dynamic and thermodynamic structures were investigated during passage of Typhoon Sinlaku (2020) over Xisha Islands in South China Sea period 28 July to 2 August 2020, mainly based on two-way rawinsonde dropsonde measurements combination with surface-based automatic weather station observations, disdrometer meas...

Examined children's ratings of attitudes and behavioral intentions toward a boy presented, on videotape, with or without symptoms of Tourette syndrome (TS). Effects of information about TS on these ratings were investigated as well as the influence of gender and grade. Children in Grades 3 and 5 were randomly assigned to one of three conditions: No TS, TS, or TS/information. On the attitude mea...

Temperature sensitivity of frog taste cells was studied. The taste cell designated Type thermosensitive (TS) I cell was depolarized by warm stimulus at 30 degrees C and hyperpolarized by cold stimulus at 10 degrees C. The taste cell designated Type TS II cell was depolarized by the cold stimulus and hyperpolarized by the warm stimulus. Menthol solution at 20 degrees C, which selectively activat...

This report describes a Ts costimulator assay and its use to analyze cofactors required for the expression of suppressor T cell function. Activation of primed MLR-Ts (alloantigen-activated suppressor T cells suppressive of mixed leukocyte reaction) to suppressor T cell factor (TsF) production typically fails in the presence of glutaraldehyde-fixed rather than irradiated allogeneic stimulator ce...

Background: Aim was to study the clinical profile, laboratory parameters and outcome of children with pediatric inflammatory multisystem syndrome temporally associated SARS-CoV-2 (PIMS-TS).Methods: This is an observational done in a PICU tertiary care teaching hospital Pune conducted over seven months starting from 1st June 31st December, 2020 which included meeting case definition PIMS-TS.Resu...

Tumor cell resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious problem often associated with increased intracellular TS. Clinically, another problem that arises from the use of TS inhibitors is toxicity, which develops, in part, because normal cells may be adversely affected by doses of inhibitor that do not impact tumor cells. To circumvent this probl...