One of the most common diseases in tropical countries is Hansen's disease. Mainly presents as Tuberculoid and lepromatous leprosy apart from its sub classification. Neuritic disease one commonly seen cases by neurologists. It can present mononeuritic form or mononeuritis multiplex with without dermatologic manifestations. Among peripheral nerves involved are greater auricular, ulnar,superficial...

INTRODUCTION: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. ME...

Lepromin, a product containing Mycobacterium leprae from patients' tissues, fails to elicit skin reactions in lepromatous patients; this non-reactivity was utilized as a means of identifying the mycobacterium isolated in mouse foot-pads from leprosy patients. To do this a suspension of acid-fast bacilli prepared from mouse foot-pads infected with a typical isolate was compared to human lepromin...

UNLABELLED Development of an effective vaccine against drug-resistant Mycobacterium tuberculosis (Mtb) is crucial for saving millions of premature deaths every year due to tuberculosis. This paper describes a web portal developed for assisting researchers in designing vaccines against emerging Mtb strains using traditional and modern approaches. Firstly, we annotated 59 genomes of Mycobacterium...

Peripheral blood monocytes from polar lepromatous leprosy (LL) patients were unable to support Mycobacterium leprae-induced in vitro lymphoproliferation of HLA-D-matched T cells from tuberculoid leprosy subjects, whereas those from responder individuals were able to do so. Monocyte-rich adherent cells from untreated LL patients released de novo soluble factors which inhibited antigen-induced ly...

INTRODUCTION Histopathological examination of skin or nerve biopsies or the demonstration of lepra bacilli in skin smears are the only laboratory means of confirming a diagnosis of leprosy.' The histological features are particularly useful in the early stages when there i s a sparsity of bacilli in skin smears. The histological changes in the skin in leprosy are p r ~ t e a n , ~ ~ and it is e...