Due to low toxicity to nontarget species and rapid degradation after its application, organophosphate (OP) remains a widely used class of pesticide. Suicidal or accidental overdose of OP can result in acute tubular necrosis. Experimental evidence shows little correlation between the renal tubular necrosis and the degree of OP-induced acetylcholinesterase inhibition, the main mechanism of OP's t...

These results demonstrate that vim entin is present in the epithelial cells of renal tubules involved in foci of nonsup-purative interstitial nephritis, one of the most common in-flammatory processes of the bovine kidney.' Vimentin is frequently expressed in human renal cell carcinomas, 10 which are assumed to arise from tubular cells, and in tubular epi-thelial cells during the course of vario...

Hormones, Growth Factors, Cell Signaling, Cell Biology and Structure Stimulation of Proximal Tubule Cell Apoptosis by Albumin Bound Fatty Acids Mediated by Peroxisome Proliferator Activated Receptor Tubulotoxic Effects of Proteinuria: The Lipid Connection Is Strengthened. There is currently little doubt that sustained high-grade proteinuria has damaging renal effects. While the mechanisms invol...

Renal tubular cell apoptosis is a significant component of obstruction-induced renal injury, and it results in a progressive loss in renal parenchymal mass during renal obstruction. Although IL-18 is an important mediator of inflammatory renal disease and renal fibrosis, its role in obstruction-induced renal tubular cell apoptosis remains unclear. To study this, male C57BL6 wild-type mice and C...

In vivo, mammalian cells proliferate within 3D environments consisting of numerous microcavities and channels, which contain a variety of chemical and physical cues. External environments often differ between normal and pathological states, such as the unique spatial constraints that metastasizing cancer cells experience as they circulate the vasculature through arterioles and narrow capillarie...

Na/H exchanger-1 (NHE1) is a ubiquitous plasma membrane Na/H exchanger typically associated with maintenance of intracellular volume and pH. In addition to the NHE1 role in electroneutral Na/H transport, in renal tubular epithelial cells in vitro the polybasic, juxtamembrane NHE1 cytosolic tail domain acts as a scaffold, by binding with ezrin/radixin/moesin (ERM) proteins and phosphatidylinosit...