We introduce a new 3D tubular intensity model in conjunction with a model fitting scheme for accurate segmentation and quantification of small tubular structures in 3D vascular images. The tubular model is formulated based on principles of the image formation process. Compared to previous straight models, the new model allows to accurately represent curved tubular structures, to directly estima...

In this paper, we present a novel quantitative description of intracellular and t-tubular Ca dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular and peripheral ...