BACKGROUND Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnormalities which are contributing factors to breast tumor progression. Genomic manipulation of hepatic FGFR4 has uncovered roles of endocrine FGF signaling in both metabolic and c...

BACKGROUND Treatment of adrenal metastasis from lung carcinoma may prolong survival in the selected patients. However, not all patients can undergo surgery; thus, minimally invasive ablation procedures such as radiofrequency ablation (RFA) and microwave ablation (MWA) have gained acceptance as alternative treatment methods. This study summarized a 5-year single-center experience regarding the e...

BACKGROUND AND OBJECTIVE Percutaneous ultrasound-guided thermal ablation is one of the major treatment methods for liver cancer. Tumor location close to the diaphragm or gastrointestinal tract was regarded as the treatment contraindication before due to poor visibility of the tumor or increased risk of thermal injury to the adjacent organs. This study used artificial pleural effusion or ascites...

PURPOSE To evaluate the safety and effectiveness of computed tomography (CT)-guided radiofrequency (RF) ablation in the palliative treatment of recurrent advanced head and neck cancers. MATERIALS AND METHODS From November 2002 to January 2005, the authors identified 14 patients (median age, 61 years) with 14 recurrent advanced primary head and neck malignancies who underwent 27 CT-guided RF a...

Microbubbles (MBs) are considered as an important enhancer for high intensity focused ultrasound (HIFU) treatment of benign or malignant tumors. Recently, different sizes of gas-filled bubbles have been investigated to improve the therapeutic efficiency of HIFU thermal ablation and reduce side effects associated with ultrasound power and irradiation time. However, nanobubbles (NBs) as an ultras...

_____________________________________________________________________________________ Abstract: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world. Although it occurs predominantly in Asia and Africa, its incidence is rising in western countries where hepatitis C infection is common. Thermal destruction has been used effectively for many years for ablation of both s...

PURPOSE We aimed to retrospectively compare the local tumor control rates between low frequency (LF) and high frequency (HF) microwave ablation devices in the treatment of <3 cm lung metastases. METHODS A total of 36 patients (55 tumors) were treated with the LF system (915 MHz) and 30 patients (39 tumors) were treated with the HF system (2450 MHz) between January 2011 and March 2016. Compute...

conclusions: catheter ablation of flutter circuit will not prevent later manifestation of af in 16% of the patients undergoing catheter ablation of the typical afl. bmi was the only independent predictor of af following catheter ablation of the typical afl. objectives; to determine long-term incidence and predictors of af after catheter ablation of typical afl. material and methods: between mar...

Radiofrequency ablation has attracted increasing attention as a minimally invasive method of treating hepatic malignancies.1 Image guidance can play an important role in enhancing the safety and effectiveness of ablative therapy. Imaging should ensure that ablation is precise, enabling complete coagulation of tumor tissue within a safety margin. The applicator should be positioned and energy de...

Regulatory T (Treg) cell infiltration constitutes a prominent feature of pancreatic ductal adenocarcinoma (PDA). However, the immunomodulatory function of Treg cells in PDA is poorly understood. Here, we demonstrate that Treg cell ablation is sufficient to evoke effective anti-tumor immune response in early and advanced pancreatic tumorigenesis in mice. This response is dependent on interferon-...