Metastasis is initiated in epithelial-derived tumors when cells at the tumor front breach the epithelial basement membrane (BM). Invasion through BMs is thought to be one of the most rate-limiting steps in cancer progression and thus is a therapeutically attractive target for halting tumor spread. Despite intense interest, it has been challenging to experimentally determine how invasive cells b...

Modeling tumor growth has proven a very challenging problem, mainly due to the fact that tumors are highly complex systems that involve dynamic interactions spanning multiple scales both in time and space. The desire to describe interactions in various scales has given rise to modeling approaches that use both continuous and discrete variables, known as hybrid approaches. This work refers to a ...