The tumor hypoxic microenvironment not only induces genetic and epigenetic changes in cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On other hand, conventional approaches which kill cells or destroy blood to block nutrition supply usually facilitate even harsher microenvironment. Thus, simultaneously relieving strained res...

Oxaliplatin (trans-l-diaminocyclohexane oxalatoplatinum; l-OHP), a third-generation platinum antitumor drug, is currently approved in combination with 5-flurouracil (5-FU)/leucovorin (FOLFOX) for standard first- and second-line treatment of metastatic or advanced-stage colorectal cancer. Despite l-OHP's better tolerability in comparison with other platinum compounds such as cisplatin and carbop...

Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in...

Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is exhausted. Inspired by the ability of nanotherapeutics to target specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to and refill hydrogel drug delivery systems. To address this possibility, hydrogels ...

A magneto-responsive energy/drug carrier that enhances deep tumor penetration with a porous nano-composite is constructed by using a tumor-targeted lactoferrin (Lf) bio-gate as a cap on mesoporous iron oxide nanoparticles (MIONs). With a large payload of a gas-generated molecule, perfluorohexane (PFH), and a hydrophobic anti-cancer drug, paclitaxel (PTX), Lf-MIONs can simultaneously perform bur...

objective(s) physiological changes in the body may be utilized as potential triggers for controlled drug delivery. based on these mechanisms, stimulus-responsive drug delivery has been developed. materials and methods in this study, a kind of poly (n-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. changes in swelling ratios and diameters of the membrane were i...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

objective(s): the aim of this work was to prepare and characterize magnetic nanoparticles (mnps) as theranostic system to act simultaneously as drug carrier and mri contrast agent. chitosan-coated mnps (cmnps) were prepared and loaded with silymarin. silymarin-loaded cmnps were characterized with various techniques and their potential as mri contrast agent was also evaluated. materials and meth...